Prion diseases, including human Creutzfeldt-Jakob disease, are infectious, intractable central neurodegenerative diseases, which are also zoonoses that commonly infect not only higher organisms but also a wide variety of animals. Pathogenic prions induce abnormal prion protein (PrP), which is...

Introduction: The functions and mechanisms of prion proteins (PrP^C) are currently unknown, but most experts believe that deformed or pathogenic prion proteins (PrP^Sc) originate from PrP^C, and that there may be plural main sites for the conversion of normal PrP^C into PrP^Sc. In order to better...

The early replication of some orally-acquired prion strains upon stromal-derived follicular dendritic cells (FDC) within the small intestinal Peyer's patches is essential to establish host infection, and for the disease to efficiently spread to the brain. Factors that influence the early...

Chronic wasting disease (CWD) is a fatal, progressive disease that affects cervid species, including Rocky mountain elk (Cervus elaphus nelsoni). There are 2 allelic variants in the elk prion protein gene: L132 (leucine) and M132 (methionine). Following experimental oral challenge with the CWD...

Prion diseases are infectious neurodegenerative disorders of humans and animals caused by misfolded forms of the cellular prion protein PrP^C. Prions cause disease by converting PrP^C into aggregation-prone PrP^Sc. Chronic wasting disease (CWD) is the most contagious prion disease with substantial...

Chronic wasting disease (CWD) is a prion disease of cervids including deer, elk, reindeer, and moose. Human consumption of cervids is common, therefore assessing the risk potential of CWD transmission to humans is critical. In a previous study, we tested CWD transmission via intracerebral...

Wild animals are under constant threat from a wide range of micro- and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti-parasite immune responses....

The unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrP^Sc, aberrant depositions of the host's cellular prion protein (PrP^C). Successive heat treatment in the presence of detergent and proteolysis by a keratinase...

Prion diseases are transmissible spongiform encephalopathies induced by the abnormally-folded prion protein (PrP^Sc), which is derived from the normal prion protein (PrP^C). Previous studies have reported that lipid rafts play a pivotal role in the conversion of PrP^C into PrP^Sc, and several...

Prion diseases are fatal infectious neurodegenerative disorders affecting both humans and animals. They are caused by the misfolded isoform of the cellular prion protein (PrP^C), PrP^Sc, and currently no options exist to prevent or cure prion diseases. Chronic wasting disease (CWD) in deer, elk and...