In order to analyse the advanced structure of prion protein in Lohmann Brown laying hen, the species barriers in prion diseases and the mechanism of conformational transition, specific primers were designed based on the gene sequence of chicken prion protein in GenBank. The ORFs of prion protein ...

Nematodes are one of the largest groups of animals on the planet. Many of them are major pathogens of humans, animals and plants, and cause destructive diseases and socioeconomic losses worldwide. Despite their adverse impacts on human health and agriculture, nematodes can be challenging to...

Cellular prion protein (PrP^C) is ubiquitously expressed in the cytomembrane of a considerable number of eukaryotic cells. Although several studies have investigated the functions of PrP^C in cell proliferation, cell apoptosis, and tumorigenesis of mammals, the correlated functions of chicken PrP^C...

Zearalenone (ZEA), also known as F-2 toxin, is a mycotoxin. Despite numerous reports of ZEA impairing livestock production performance and fertility, little information is available, including information about the mechanism underlying damage to cell metal ion transport. Copper, which is essential...

Background: Most haematophagous organisms constantly suck the host's haemoglobin, which produces toxic free haem. This toxic haem aggregation into the nontoxic crystallisation complex known as haemozoin represents one of the most important detoxification pathways in living organisms, but very...

In order to investigate the apoptosis of Sertoli cell (SC) induced by zearalenon (ZEA), the primary SC was used as the experiment material, and exposed to different concentration of ZEA (0, 5, 10, 20 µmol/L) for 24 h. The CCK-8 method was used to estimate cells viability; the flow cytometry was...

Determination of the transcription level of cellular prion protein (PrP^C) is essential for understanding its role in organisms and revealing mechanism of susceptibility and resistance to scrapie. However, the expression of prion protein (PrP) mRNA in sheep has not been quantified in great detail...

Neospora caninum is an apicomplexan parasite that infects many mammals and remains a threatening disease worldwide because of the lack of effective drugs and vaccines. Our previous studies demonstrated that N. caninum 14-3-3 protein (Nc14-3-3), which is included in N. caninum extracellular vesicles ...

Tapeworms are infamous and highly successful invasive parasites in aquatic animals, especially in fish. However, tapeworm-caused diseases in soft-shelled turtles are rarely discovered. In this study, a case of cultured Chinese soft-shelled turtle (Pelodiscus sinensis) infected with tapeworm in...

Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that poses a serious threat to human health and the swine industry. The survival and travel in the bloodstream are the important causes for SS2, contributing to bacteremia, septicemia even septic shock. However, the related...