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The UK Foreign, Commonwealth and Development Office (FCDO) is supporting CABI to manage a knowledge, learning and evidence platform focused on One Health to facilitate learning and evidence synthesis. The One Health Hub will engage with stakeholders to identify research gaps and promote evidence-informed research and policy decision making in One Health. The Juno Evidence Alliance will lead the One Health Hub’s work to synthesize evidence on One Health issues and will be working with the secretariat and communication teams to share and debate evidence widely. The One Health Hub will work closely with the FAO One Health Knowledge Nexus and seek to engage with the One Health Quadripartite and One Health High Level Expert Panel.