Food security continues to be significantly impacted by a growing world population, changing climate, increasing food prices and environmental burden. One of the key challenges in reducing crop losses due to pests and diseases is timely delivery of appropriate, actionable extension advice to farmers. Information and communication technology (ICT) has the potential to improve services that connect smallholder farmers to new resources and information, helping to build their knowledge and ultimately improve their livelihoods. Such ICT-driven services have seen rapid growth over the past few years, and CABI has been harnessing this technology in several programmes. This chapter provides insight into digital interventions of the global, CABI-led programme, Plantwise, which aims to assist stakeholders in developing countries to improve their plant health systems by strengthening linkages among all actors involved, so that they can prevent and manage pest outbreaks more effectively. An overview of digital interventions piloted and tested under the umbrella of the Plantwise programme is illustrated with selected case studies. Interventions include pest diagnosis and management advice delivered via a website, plant health data collection, using a customized mobile application, and educational simulation games for ongoing support.