This paper described the broad aspects of the Center for Agriculture and Bioscience International (CABI)-led Plantwise program which supports and complements national plant health system including extension programs in developing countries. Essentially, Plantwise provided smallholder farmers with better access to advice and information – and thus losing less of what they grow due to plant health problems. The three key components of Plantwise were briefly discussed, viz., plant clinics run by trained plant doctors and supported by a range of stakeholders including agro-dealers, the Knowledge Bank and Monitoring and Evaluation. Some aspects of these components were illustrated using brassicas and the concomitant pests and diseases. Aspects examined included the types of brassica crops that the farmers bring to the plant clinics, the key problems diagnosed by plant doctors and their management recommendations. The paper also included examples of farmer-friendly extension materials such as pest and disease factsheets and the pest management decision guide. The opportunities and challenges to implementing Plantwise in target countries are also addressed.