This evidence brief synthesizes findings from the STAR IDAZ IRC 2024 mapping report and a March 2025 OH funding workshop in Nairobi and subsequent report. The workshop involved over 40 participants from the Quadripartite (WHO, FAO, WOAH, UNEP), the African Development Bank, and other key stakeholders to identify 13 core challenges to OH research funding and co-develop practical solutions for funders and scientists. The evidence brief contributes to a One Health research roadmap produced by the One Health Hub with support from UK International Development.