Plantwise is a global programme led by CAB International that has been introduced in more than 30 countries since 2011. It is presented in this chapter as a case study illustrating the use of innovative approaches and tools in pest management. Plantwise puts emphasis in accurate pest diagnosis as an essential requisite for effectiveness of recommendations given to farmers in managing pests at farm level, with a strong focus on production practices by smallholder farmers in developing countries. Training of intermediaries between technology developers and smallholder farmers in diagnosing problems that farmers detect in their crops is recognized as the key starting point in pest management. The intermediaries, herein referred to as plant doctors, are specially trained government agro-advisory service providers, empowered through training on how to diagnose problems with plant Tools for pest and disease management by stakeholders Tools for pest and disease management by stakeholders health, operate plant clinics and give good advice to farmers based on integrated pest management (IPM) principles. Plant clinics are an extension tool that is based on a similar approach to human health clinics. Not only do the plant clinics serve as points from which to advise farmers, but they are also frontline facilities for diagnosing and documenting the presence of pests in farmers’ fields.