Invasive Alien Species (IAS) are widely recognized as one of the major global change factors; they now affect all major economic sectors within and between countries. The estimated impacts of IAS nationally can be colossal and run into billions of US$ annually. There has been much international response to the threats of IAS and suggested management frameworks (prevention and control) and tools are freely available. However, responses at national, local and even regional levels have been patchy or non-existent across the globe. In large part, this is because the broader impacts of IAS have been championed by environment sectors since the 1980s that traditionally do not house the frameworks for addressing such threats to economies. Other factors are also important such as the lack of detailed studies on the impacts of IAS particularly on rural livelihoods and the lack of inter-ministerial discussion and collaboration over the IAS issue within countries. Because of this, important tools for the control of IAS such as introduction of biological control are underutilized. There is now an urgent need for fully comprehensive management packages to be developed and implemented at national levels across the globe. These should include major stakeholder engagements and inputs.