The American Institutes for Research (AIR) was contracted by CABI to design and implement a mixed-methods impact assessment of Plantwise in Pakistan and to conduct the necessary data collection, analysis, and reporting. This report presents the results for the evaluation of Plantwise–Pakistan (PW-P) as implemented in Punjab, the province where PW-P has been implemented for the longest period and that has the highest levels of plant clinic coverage in the country. We used qualitative and quantitative methods to answer four research questions. We used qualitative methods to assess the changes that PW-P brings to the plant health system, assess program sustainability, and evaluate the process of the PW implementation in the field. We used quantitative methods to identify farm-level impacts using a quasi-experimental approach in 8 districts of Punjab province. We collected one round of data at the end of 2018. A total of 1,805 farmers from 120 villages were interviewed to estimate the impacts of attending plant clinics. Lastly, we also used administrative quantitative data on program costs to conduct a cost-benefit analysis of the program.