Elevations in circulating trimethylamine N-oxide (TMAO) and its precursors are observed in humans and dogs with heart failure and are associated with adverse outcomes in people. Dietary intervention that reduces or excludes animal ingredients results in rapid reduction of plasma TMAO and TMAO...

Since a few years, a lot of cases of canine dilated cardiomyopathy (DCM) were reported as possibly linked to specific kinds of pet foods: "no grain" foods, or foods rich in legumes like peas and lentils. Those cases seem different to the previous food- associated DCM cases that had been described...

Background: A recent study showed higher high-sensitivity cardiac troponin I (hs-cTnI) concentrations in healthy dogs eating grain-free (GF) compared to those eating grain-inclusive (GI) diets. Hypothesis/Objectives: Healthy dogs with subclinical cardiac abnormalities eating GF diets at baseline...

This review provides a state-of-the-art overview on recent advances in systems biology in canine cardiac disease, with a focus on our current understanding of bioenergetics and amino acid metabolism in myxomatous mitral valve disease (MMVD). Cross-species comparison is drawn to highlight the...

Whether it is used for short-term management before or immediately after surgical correction or long-term medical management, diet can play an instrumental role and can provide a beneficial effect on the quality of life of portosystemic shunts (PSS) patients. The most substantial consequences of...

Feline hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats. This review article takes an in-depth look at the role of nutrition as part of effective multimodal management of HCM, examining specific nutrients that aid in improving the quality of life for cats with HCM....

Dilated cardiomyopathy (DCM), caused by genetic and environmental factors, usually progresses to heart failure, a major cause of death in elderly people. A diet-associated form of DCM was recently identified in pet dogs eating non-traditional (NT) diets. To identify potential dietary causes, we...

OBJECTIVE: To determine breed-specific reference intervals for whole blood (WB) and plasma taurine concentrations in adult, overtly healthy Cavalier King Charles Spaniels (CKCSs) and determine whether taurine concentrations differ across preclinical myxomatous mitral valve disease (MMVD) stages or...

The most common cause of heart failure in dogs is myxomatous mitrai valve disease (MMVD), which accounts for approximately 75% of canine heart disease cases and is especially common in smaller dogs. Although low-sodium diets have been recommended for humans with heart diseases for decades, there is ...

This study reports the efficacy of the vasodilator sodium nitroprusside (SNP), for treatment of acute cardiogenic pulmonary edema in dogs. For this study, the patients were divided into the SNP only treatment group, the SNP, furosemide and dobutamine treatment group, and non-SNP treatment group....