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News Article

Study of canine mitral valve disease and congestive heart failure provides clues to target therapies in dogs and human mitral valve prolapse.

Date
18 July 2017
Abstract

Objectives: Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors for poorer prognosis will decrease...

Author(s)
Hezzell, M. J.; Boswood, A.; López-Alvarez, J.; Lötter, N.; Elliott, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2017, 19, 4, pp 325-338
Abstract

Objectives: To assess the prevalence of functional ejection murmurs and murmurs of mitral regurgitation (MR) due to myxomatous mitral valve disease in healthy whippets; to assess the diagnostic value of auscultation to detect MR; and investigate the relationship between age and presence of...

Author(s)
Stepien, R. L.; Kellihan, H. B.; Fuentes, V. L.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2017, 19, 4, pp 317-324
AbstractFull Text

Small-breed dogs (n=168; weight <15 kg) diagnosed with myxomatous mitral valve degeneration based on a routine clinical examination, radiology, electrocardiography, and echocardiography at the Seoul National University Veterinary Medical Teaching Hospital were included in this study. Survival periods were determined, and there were significant differences in survival rates among the three International Small Animal Cardiac Health Council classes. The mean follow-up period was 14.3±12.1 months. Univariate analysis revealed that dyspnea, pulmonary edema, and vertebral heart score were significantly associated with survival time (p<0.05). Additionally, age, left atrial-to-aortic root ratio, ejection fraction, and left ventricular end diastolic volume were associated with an increased risk of death (p<0.1), while body weight, body condition score, systolic blood pressure, arrhythmia, syncope, fractional shortening, and end systolic volume were not associated with an increased risk of death. These results suggest that among the assessed variables dyspnea, pulmonary edema, and vertebral heart score could be useful prognostic factors for providing patient information to owners.

Author(s)
Kim HyunTae; Han SeiMyoung; Song WooJin; Kim BoEun; Choi MinCheol; Yoon JungHee; Youn HwaYoung
Publisher
Korean Society of Veterinary Science, Seoul, Korea Republic
Citation
Journal of Veterinary Science, 2017, 18, 3, pp 369-376
Abstract

Introduction: Older small breed dogs are considered at risk for heart failure secondary to chronic mitral valve disease. However, few data are available on the onset of this disease in such dogs. This study was performed to determine if auscultation alone can be used to eliminate clinically...

Author(s)
Garncarz, M.; Parzeniecka-Jaworska, M.; Hulanicka, M.; Jank, M.; Szaluś-Jordanow, O.; Kurek, A.
Publisher
De Gruyter Open, Warsaw, Poland
Citation
Journal of Veterinary Research, 2017, 61, 3, pp 363-366
Abstract

Background: Biologic variability (BV) is one aspect of interpreting changes in biomarker concentrations known to be clinically important in people with cardiac disease, but it has not been adequately addressed in dogs so far. Objectives: The purpose of the study was to determine BV of cardiac...

Author(s)
Winter, R. L.; Saunders, A. B.; Gordon, S. G.; Miller, M. W.; Fosgate, G. T.; Suchodolski, J. S.; Steiner, J. M.
Publisher
Wiley, Boston, USA
Citation
Veterinary Clinical Pathology, 2017, 46, 2, pp 299-307
Abstract

Background: The median age at presentation for dogs with patent ductus arteriosus (PDA) is <6 months of age, and closure is associated with a decrease in heart size and increased survival time, which are not well described in older dogs. Objectives: To describe the clinical characteristics of dogs with PDA ≥5 years of age at the time of presentation to a veterinary referral hospital. Animals: 35 client-owned dogs. Methods: Retrospective ...

Author(s)
Boutet, B. G.; Saunders, A. B.; Gordon, S. G.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2017, 31, 3, pp 685-690
Abstract

Background: The assessment of left atrial (LA) function by 2-dimensional speckle tracking echocardiography (STE) holds important clinical implications in human medicine. Few similar data are available in dogs. Objectives: To assess LA function by STE in dogs with and without myxomatous mitral valve ...

Author(s)
Toaldo, M. B.; Romito, G.; Guglielmini, C.; Diana, A.; Pelle, N. G.; Contiero, B.; Cipone, M.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2017, 31, 3, pp 641-649
Abstract

This article summarizes the results of the EPIC study conducted for five years in 36 veterinary centres on the beneficial effects of pimobendan to prolong the period preceding the appearance of clinical signs of left congestive heart failure in degenerative mitral valve disease in dogs. The...

Author(s)
Rose, H.
Publisher
Newsmed, Paris, France
Citation
Point Vétérinaire, 2017, 48, 378(Part 1), pp 8-9
Abstract

This paper reports on a case of degenerative mitral valve disease in a 8-year-old Cavalier King Charles Spaniel. Highlights focused on the diagnosis and treatment of the animal.

Author(s)
Bertrand, A.; Bouhsina, N.; Fusellier-Tesson, M.
Publisher
Newsmed, Paris, France
Citation
Point Vétérinaire, 2017, 48, 378(Part 1), pp 64

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