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Abstract

Torasemide is a loop diuretic licensed in dogs for cardiogenic pulmonary oedema. The aim of this pharmacokinetic-pharmacodynamic (PK/PD) study was to define an optimally effective dosage regimen based on preclinical data. In a first study, 5 dogs received once-daily oral torasemide (0, 0.1, 0.2,...

Author(s)
Pelligand, L.; Guillot, E.; Geneteau, A.; Guyonnet, J.; Magnier, R.; Elliott, J.; Peyrou, M.; Jacobs, M.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2020, 6, April,
Abstract

Background: Torasemide is a potent loop diuretic with potential to treat congestive heart failure (CHF) in dogs. ObjectiveEvaluate the efficacy and safety of torasemide compared to furosemide in dogs with first occurrence of CHF caused by degenerative mitral valve disease (DMVD). AnimalsThree...

Author(s)
Besche, B.; Blondel, T.; Guillot, E.; Garelli-Paar, C.; Oyama, M. A.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 5, pp 1746-1758
Abstract

Background: In dogs with congestive heart failure (CHF), the efficacy of torasemide, a loop diuretic, has been demonstrated. However, unlike in dogs and humans little has been described about the use of torasemide in the cat with spontaneous CHF. The objectives of this retrospective study were...

Author(s)
Poissonnier, C.; Ghazal, S.; Passavin, P.; Alvarado, M. P.; Lefort, S.; Trehiou-Sechi, E.; Saponaro, V.; Barbarino, A.; Cave, J. D.; Marchal, C. R.; Depré, B.; Vannucci, E.; Tissier, R.; Verwaerde, P.; Chetboul, V.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2020, 16, 339, pp (16 September 2020)
Abstract

PICO question: In dogs with congestive heart failure, does the use of torasemide as a first line diuretic result in a superior survival time when compared to furosemide? Clinical bottom line: Category of research question: Treatment The number and type of study designs reviewed: Five studies were...

Author(s)
Packham, L.
Publisher
RCVS Knowledge, London, UK
Citation
Veterinary Evidence, 2020, 5, 4,
Abstract

Background: Furosemide is the only loop diuretic recommended by the ACVIM consensus guidelines for treatment of congestive heart failure (CHF) in dogs related to degenerative mitral valve disease (DMVD). Torasemide is another potent loop diuretic with a longer half-life and a higher...

Author(s)
Chetboul, V.; Pouchelon, J. L.; Menard, J.; Blanc, J.; Desquilbet, L.; Petit, A.; Rougier, S.; Lucats, L.; Woehrle, F.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2017, 31, 6, pp 1629-1642
Abstract

Torasemide is a loop diuretic that is more potent and has a longer duration of action than furosemide. In clinical trials, torasemide seemed to be similar in effectiveness to furosemide for treating the clinical signs of congestive heart failure (CHF) (cough, dyspnoea, exercise tolerance and oedema ...

Publisher
Mixolydian Publications Limited, Winchester, UK
Citation
Veterinary Prescriber, 2019, No.October, pp unpaginated
Abstract

A pharmacokinetic/pharmacodynamic modelling approach was used to determine a dosage regimen which maximizes diuretic efficiency of torasemide in dogs. Kinetic profiles of plasma concentration, torasemide excretion rate in urine (TERU) and diuresis were investigated in 10 dogs after single oral...

Author(s)
Paulin, A.; Schneider, M.; Dron, F.; Woehrlé, F.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2016, 39, 6, pp 547-559
Abstract

The pharmacokinetics, efficacy and adverse effects of torasemide compared to furosemide in the treatment of oedema in dogs are presented.

Author(s)
Louzier, V.; Étevenot, A.; Mallem, Y.
Publisher
Newsmed, Paris, France
Citation
Point Vétérinaire, 2018, 49, 387 (Part 1), pp 17
AbstractFull Text

Author(s)
Besche, B.; Guillot, E.; Blondely, T.; Oyama, M.
Publisher
ASIS Biomedia s.l., Saragossa, Spain
Citation
Argos - Informativo Veterinario, 2020, 219, pp 44-45
Abstract

Torasemide is a new loop diuretic that combines the effects of furosemide and spironolactone. There are no reports on the effects of torasemide in cats and dogs. This study compared the diuretic effects of furosemide and torasemide in cats and dogs. Cats with pressure overload cardiac hypertrophy...

Author(s)
Uechi, M.; Matsuoka, M.; Kuwajima, E.; Kaneko, T.; Yamashita, K.; Fukushima, U.; Ishikawa, Y.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2003, 65, 10, pp 1057-1061

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