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Abstract

OBJECTIVE: To determine whether target values for pharmacokinetic-pharmacodynamic (PK-PD) indices against selected canine pathogens were achievable for pradofloxacin in various canine fluids and leukocytes. ANIMALS: 8 healthy adult hounds (experiments 1 and 2) and 6 healthy adult dogs (experiment...

Author(s)
Boothe, D. M.; Bush, K. M.; Boothe, H. W.; Davis, H. A.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2018, 79, 12, pp 1268-1276
Abstract

We investigated in vitro activity of a novel veterinary fluoroquinolone, pradofloxacin, against methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates and compared with other fluoroquinolones. A total of 38 MRSP isolates were subjected to agar disk diffusion tests for sensitivity to ...

Author(s)
Kizerwetter-Świda, M.; Chrobak-Chmiel, D.; Rzewuska, M.; Binek, M.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2016, 28, 5, pp 514-518
Abstract

Pradofloxacin is a third-generation fluoroquinolone, licensed in the EU for use in a range of indications in the dog and cat and authorized more recently in the USA for one therapeutic indication (skin infections) in the cat. This review summarizes and appraises current knowledge on the...

Author(s)
Lees, P.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2013, 36, 3, pp 209-221
Abstract

Background: Uncomplicated urinary tract infections (UTI) are often empirically treated with antimicrobials. Typically, these infections are treated for 7-14 days. Shorter durations of therapy have been evaluated extensively in human medicine and for some veterinary medicines with the aim to reduce...

Author(s)
Vercelli, A.; Mottet, J. M.
Publisher
Point Vétérinaire Italie s.r.l., Milano, Italy
Citation
Summa, Animali da Compagnia, 2017, 34, 5, pp 55-62
Abstract

Background: Pradofloxacin, a newly developed 8-cyano-fluoroquinolone, show enhanced activity against Gram-positive organisms and anaerobes to treat canine and feline bacterial infections. The purpose of this cross-over study was to measure the unbound drug concentration of pradofloxacin in the...

Author(s)
Hauschild, G.; Rohn, K.; Engelhardt, E.; Sager, M.; Hardes, J.; Gosheger, G.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2013, 9, 32, pp (14 February 2013)
Abstract

Background: Moxifloxacin is a fourth-generation fluoroquinolone (FQ) that is approved for use in people to treat a variety of infections. Some veterinary microbiology laboratories report moxifloxacin in culture and sensitivity profiles for Staphylococcus pseudintermedius and S. schleiferi albeit...

Author(s)
Plowgian, C.; Blondeau, J. M.; Levinson, M.; Rosenkrantz, W.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Dermatology, 2019, 30, 6, pp 481-e142
Abstract

Background: The oral hygiene in dogs depends mostly on the quality of consumed food and plaque removal performed by the owner. In neglected cases severe, irreversible periodontitis with pockets containing anaerobic bacterial flora could evolve in months or years. Objectives: The aim of this study...

Author(s)
Kalla, H.; Lajos, Z.; Dunay, M. P.
Publisher
Herman Ottó Institute Nonprofit Ltd., Budapest, Hungary
Citation
Magyar Állatorvosok Lapja, 2018, 140, 10, pp 621-633
Abstract

ComPath is a pan-European resistance monitoring programme collecting bacterial pathogens from dogs and cats. We present data for respiratory tract infection (RTI) isolates collected between 2008 and 2010. Antimicrobial minimal inhibitory concentrations (MICs) were determined and susceptibility...

Author(s)
Morrissey, I.; Moyaert, H.; Jong, A. de; El-Garch, F.; Klein, U.; Ludwig, C.; Thiry, J.; Youala, M.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Microbiology, 2016, 191, pp 44-51
AbstractFull Text

The aim of the study was to analyse the influence of enrofloxacin and pradofloxacin administered orally for 14 days on the ECG in dogs. The ECG was performed before and after a 14 day period of quinolone administration. There was an increase in the QTc and the TpTe interval in the group treated...

Author(s)
Cepiel, A.; Noszczyk-Nowak, A.; Cekiera, A.; Popiel, J.; Pasławska, U.
Publisher
Polish Academy of Sciences, Committee of Veterinary Sciences, Olsztyn-Kortowo II, Poland
Citation
Polish Journal of Veterinary Sciences, 2017, 20, 3, pp 567-572
Abstract

Aims: To present antimicrobial susceptibilities for bacteria from dogs and cats with respiratory tract infection (RTI) across Europe in 2013-2014 and compare with data from 2008-2010. Methods and results: Minimal inhibitory concentrations were determined for 464 isolates following Clinical and...

Author(s)
Moyaert, H.; Jong, A. de; Simjee, S.; Rose, M.; Youala, M.; El-Garch, F.; Vila, T.; Klein, U.; Rzewuska, M.; Morrissey, I.
Publisher
Wiley, Oxford, UK
Citation
Journal of Applied Microbiology, 2019, 127, 1, pp 29-46

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