OBJECTIVE: To determine the physiochemical properties and pharmacokinetics of 3 midazolam gel formulations following buccal administration to dogs. ANIMALS: 5 healthy adult hounds. PROCEDURES: In phase 1 of a 2-phase study, 2 gel formulations were developed that contained 1% midazolam in a...

Objectives: To determine the frequency, severity and duration of adverse events including myoclonus, pain on injection, hypersalivation, regurgitation and apnoea after administration of midazolam or saline followed by etomidate in hydromorphone premedicated dogs. Materials and Methods: Dogs...

Background: Midazolam delivered by continuous rate infusion (CRI) might be effective in dogs with cluster seizures (CS) or status epilepticus (SE). Objective: To describe the use and safety of midazolam CRI in dogs with CS or SE. Animals: One-hundred six client-owned dogs presenting to a veterinary ...

Six dogs irrespective of age and sex, categorised as class I or II as per American Society of Anaesthesiologists (ASA) classification, presented to Department of Veterinary Surgery & Radiology for various elective surgeries were selected for this study. All the animals under study were...

PICO question: In healthy dogs, does the use of diazepam or midazolam administered in co-induction with propofol result in a reduction in the dose of propofol required to induce anaesthesia and a decrease in adverse cardiovascular and respiratory events? Clinical bottom line: Category of research...

The purpose of this study was to compare the hemodynamic effects of four different combinations of midazolam and opioids in healthy dogs. Twenty-four healthy dogs were divided in four groups (n = 6) using intramuscular midazolam 0.3 mg/kg and morphine 0.3 mg/kg (G_MOR), methadone 0.3 mg/kg (G_MET),...

Objective: To determine the alfaxalone dose reduction during total intravenous anaesthesia (TIVA) when combined with ketamine or midazolam constant rate infusions and to assess recovery quality in healthy dogs. Study design: Prospective, blinded clinical study. Animals: A group of 33 healthy,...

Objective: To evaluate drug interactions between fluconazole and the intravenous (IV) anesthetic induction agents, ketamine and midazolam. Study design: Randomized parallel study. Animals: A group of 12 adult healthy Beagle dogs. Methods: Dogs were randomly allocated to two groups of six dogs. Dogs ...

The purpose of this study was to assess the effects of midazolam combined with morphine or butorphanol on echocardiographic variables of healthy dogs. Twenty-four dogs of various breeds aged 34.33 ± 23.41 months and weighing 8.1 ± 4.7 kg were enrolled in the study. Subjects were randomly allocated...

This blinded, randomized, prospective study evaluated the sedative and physiologic effects of a combination of alfaxalone and methadone with or without midazolam in adult dogs. Sixteen dogs received methadone (0.5 mg/kg body weight) and alfaxalone (1 mg/kg body weight), either with or without ...