OBJECTIVE: To determine the physiochemical properties and pharmacokinetics of 3 midazolam gel formulations following buccal administration to dogs. ANIMALS: 5 healthy adult hounds. PROCEDURES: In phase 1 of a 2-phase study, 2 gel formulations were developed that contained 1% midazolam in a...

Objective: To evaluate drug interactions between fluconazole and the intravenous (IV) anesthetic induction agents, ketamine and midazolam. Study design: Randomized parallel study. Animals: A group of 12 adult healthy Beagle dogs. Methods: Dogs were randomly allocated to two groups of six dogs. Dogs ...

Objective: To determine the alfaxalone dose reduction during total intravenous anaesthesia (TIVA) when combined with ketamine or midazolam constant rate infusions and to assess recovery quality in healthy dogs. Study design: Prospective, blinded clinical study. Animals: A group of 33 healthy,...

Objective: To evaluate selected effects of midazolam or lidocaine administered prior to etomidate for co-induction of anesthesia in healthy dogs. Study design: Prospective crossover experimental study. Animals: A group of 12 healthy adult female Beagle dogs. Methods: Dogs were premedicated with...

Objective: To determine the dose and cardiopulmonary effects of propofol alone or with midazolam for induction of anesthesia in American Society of Anesthesiologists status ≥III dogs requiring emergency abdominal surgery. Study design: Prospective, randomized, blinded, clinical trial. Animals: A...

This blinded, randomized, prospective study evaluated the sedative and physiologic effects of a combination of alfaxalone and methadone with or without midazolam in adult dogs. Sixteen dogs received methadone (0.5 mg/kg body weight) and alfaxalone (1 mg/kg body weight), either with or without ...

Objective: To assess the sedative effects, propofol sparing properties and impact on quality of induction and intubation of intravenous (IV) medetomidine and midazolam administered consecutively at different doses compared to medetomidine alone in healthy dogs for premedication. Study design:...

Objective: To determine whether the use of a single dose of midazolam affects quality and duration of the recovery period in healthy dogs undergoing elective castration or ovariohysterectomy. Study design: Prospective, randomized, placebo-controlled, masked clinical trial. Animal population:...

OBJECTIVE: To evaluate the sedative and cardiorespiratory effects of IM administration of alfaxalone and butorphanol combined with acepromazine, midazolam, or dexmedetomidine in dogs. ANIMALS: 6 young healthy mixed-breed hounds. PROCEDURES: Dogs received each of 3 treatments (alfaxalone [2 mg/kg]...

Objective: To qualitatively assess the co-induction of anaesthesia with midazolam and alfaxalone and to determine cardiovascular or respiratory alterations compared with alfaxalone alone. Study design: A randomized, blinded, clinical trial. Animals: A total of 29 American Society of...