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Abstract

The aim of this 6-month, randomized, blinded, controlled clinical trial was to compare the efficacy and safety of aminosidine-allopurinol combination with that of meglumine antimoniate-allopurinol combination for the treatment of leishmaniosis in dogs without stage III or IV chronic kidney disease. ...

Author(s)
Kasabalis, D.; Chatzis, M. K.; Apostolidis, K.; Petanides, T.; Athanasiou, L. V.; Xenoulis, P. G.; Mataragka, A.; Ikonomopoulos, J.; Leontides, L. S.; Saridomichelakis, M. N.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Experimental Parasitology, 2020, 214,
Abstract

Sex-associated hormones such as testosterone have been demonstrated to modulate immune responses, which can result in different disease outcomes. The present study was aimed at evaluating the efficacy of a gonadotropin-releasing hormone GnRH agonist implant as deslorelin acetate in association with ...

Author(s)
Pugliese, M.; Biondi, V.; Quartuccio, M.; Cristarella, S.; Emmanuele, G.; Marino, G.; Liotta, L.; Passantino, A.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2021, 11, 2,
Abstract

Background: Visceral leishmaniosis is a potentially life-threatening illness caused by a protozoan parasite of the genus Leishmania. It is found mainly in areas where both the parasite and its vector are endemic and is one of the most challenging infectious diseases in the world to control. HIV...

Author(s)
Manna, L.; Corso, R.; Galiero, G.; Cerrone, A.; Muzj, P.; Gravino, A. E.
Publisher
BioMed Central Ltd, London, UK
Citation
Parasites and Vectors, 2015, 8, 289, pp (28 May 2015)
Abstract

This study examines correlations among serum proteins, clinical score, body weight and kidney function biomarkers after a standard treatment course (meglumine antimoniate plus allopurinol) in twelve Canine leishmaniosis (CanL) patients at the three times points pre treatment, after treatment and...

Author(s)
Daza González, M. A.; Miró, G.; Fermín Rodríguez, M.; Rupérez Noguer, C.; Fragío Arnold, C.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2019, 126, pp 131-138
Abstract

Canine leishmaniosis (CanL) caused by Leishmania infantum is a zoonotic disease of global concern. Antileishmanial drug therapies commonly used to treat sick dogs improve their clinical condition, although when discontinued relapses can occur. Thus, the current study aims to evaluate the effect of...

Author(s)
Santos, M. F.; Alexandre-Pires, G.; Pereira, M. A.; Marques, C. S.; Gomes, J.; Correia, J.; Duarte, A.; Gomes, L.; Rodrigues, A. V.; Basso, A.; Reisinho, A.; Meireles, J.; Santos-Mateus, D.; Brito, M. T. V.; Tavares, L.; Santos-Gomes, G. M.; Fonseca, I. P. da
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2019, 6, October, pp 362
Abstract

Hepatic fibropoiesis in canine visceral leishmaniasis (CVL) were evaluated by histological (morphometrical collagen deposition) and immunohistochemical assays characterizing alpha-actin (α-SMA), vimentin, calprotectin (L1 antigen), and TGF-β in 46 naturally infected dogs with Leishmania infantum...

Author(s)
Castro, R. S.; Amorim, I. F. G. de; Pereira, R. A.; Silva, S. M.; Pinheiro, L. J.; Pinto, A. J. W.; Azevedo, E. G.; Demicheli, C.; Caliari, M. M. V.; Mosser, D. M.; Michalick, M. S. M.; Frezard, F. J. G.; Tafuri, W. L.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2018, 250, pp 22-29
AbstractFull Text

In Canine leishmaniosis (CanL) kidneys are affected in virtually all dogs. Treatment of CanL is limited in Europe to two registered drugs: meglumine antimoniate and miltefosine. This study evaluated the clinical, toxicological and pathological effects of both drugs in eight healthy Beagle dogs...

Author(s)
Bianciardi, P.; Vischer, C.; Brovida, C.; Valente, M.; Aresu, L.; Cavicchioli, L.; Castagnaro, M.
Publisher
Edizioni SCIVAC, Cremona, Italy
Citation
Veterinaria (Cremona), 2009, 23, 4, pp 33-39
Abstract

A retrospective study was performed using 53 client owned dogs with leishmaniasis to determine whether the degree of proteinuria, evaluated by the urine protein/creatinine ratio (UP/C), changes following treatment with meglumine antimoniate and allopurinol. Medical records of dogs with...

Author(s)
Pierantozzi, M.; Roura, X.; Paltrinieri, S.; Poggi, M.; Zatelli, A.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2013, 49, 4, pp 231-236
Abstract

The treatment of dogs naturally infected with Leishmania infantum using meglumine antimoniate (MA) encapsulated in conventional liposomes (LC) in association with allopurinol has been previously reported to promote a marked reduction in the parasite burden in the main infection sites. Here, a new...

Author(s)
Santos, C. C. P. dos; Ramos, G. S.; Paula, R. C. de; Faria, K. F.; Moreira, P. O. L.; Pereira, R. A.; Melo, M. N.; Tafuri, W. L.; Demicheli, C.; Ribeiro, R. R.; Azevedo, E. G.; Monte Neto, R. do; Silva, S. M. da; Frézard, F.
Publisher
American Society for Microbiology (ASM), Washington, D.C., USA
Citation
Antimicrobial Agents and Chemotherapy, 2020, 64, 7,
Abstract

Background: C-reactive protein (CRP) and paraoxonase 1 (PON1) might increase and decrease in canine leishmaniasis (CanL), and both can rapidly normalize after therapy. Recently, supplementation of domperidone with conventional therapy, increasing the activity of cells involved in acute phase...

Author(s)
Paltrinieri, S.; Ibba, F.; Barbè, F.; Rossi, G.
Publisher
Wiley, Boston, USA
Citation
Veterinary Clinical Pathology, 2020, 49, 4, pp 618-623

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