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Abstract

Background: Angiotensin-converting enzyme 2 (ACE2) is a homologue of angiotensin-converting enzyme (ACE) and produces angiotensin peptides (APs), such as angiotensin 1-9 and 1-7 that are vasodilatory and natriuretic, and act to counterbalance angiotensin II. Hypothesis: Evidence of ACE2 can be...

Author(s)
Larouche-Lebel, É.; Loughran, K. A.; Oyama, M. A.; Solter, P. F.; Laughlin, D. S.; Sánchez, M. D.; Assenmacher, C. A.; Fox, P. R.; Fries, R. C.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 4, pp 1571-1584
Abstract

Previous studies have demonstrated the presence of Leishmania infantum amastigotes in the colonic mucosa of seropositive sick dogs. However, there are no studies that have investigated the presence of L. infantum infection in dogs diagnosed with inflammatory bowel disease (IBD). The aims of this...

Author(s)
Casanova, M. I.; Martín, S.; Marco, A.; Solano-Gallego, L.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Comparative Pathology, 2019, 167, pp 12-17
Abstract

Background: Gastrointestinal stromal tumors (GISTs) are uncommon intestinal neoplasms in the dog. Literature regarding adjunctive therapy for GISTs in dogs is sparse. High-risk GISTs in humans respond to tyrosine kinase inhibition in the adjuvant setting. Objectives: To review cases of toceranib...

Author(s)
Berger, E. P.; Johannes, C. M.; Jergens, A. E.; Allenspach, K.; Powers, B. E.; Du YingZhou; Mochel, J. P.; Fox, L. E.; Musser, M. L.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 6, pp 2045-2053
Abstract

Background: Lymphatic endothelial cell (LEC) immunohistochemical markers have identified intestinal lymphatic vasculature abnormalities in humans with inflammatory bowel disease, but have not been used to evaluate intestinal lymphatic vasculature in a group of dogs with chronic inflammatory...

Author(s)
Wennogle, S. A.; Priestnall, S. L.; Suárez-Bonnet, A.; Soontararak, S.; Webb, C. B.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 4, pp 1669-1676
Abstract

Background: Cell blocks and immunohistochemistry (IHC) are increasingly recognized as being complementary tools for cytologic diagnostics, especially for neoplastic diseases. Objectives: The study aimed to evaluate the utility of cell tube block (CTB) IHC for refining the diagnosis of effusions in ...

Author(s)
Marcos, R.; Marrinhas, C.; Malhão, F.; Canadas, A.; Santos, M.; Caniatti, M.
Publisher
Wiley, Boston, USA
Citation
Veterinary Clinical Pathology, 2019, 48, 1, pp 50-60
Abstract

Objective: To define and compare clinical characteristics of canine primary appendicular hemangiosarcoma (HSA) and telangiectatic osteosarcoma (tOSA), including signalment, presentation, response to treatment, and prognosis. Study design: Multi-institutional retrospective study. Animals: Seventy ...

Author(s)
Giuffrida, M. A.; Kamstock, D. A.; Selmic, L. E.; Pass, W.; Szivek, A.; Mison, M. B.; Boston, S. E.; Fox, L. E.; Robat, C.; Grimes, J. A.; Maritato, K. C.; Bacon, N. J.
Publisher
Wiley, Boston, USA
Citation
Veterinary Surgery, 2018, 47, 6, pp 774-783
Abstract

Background: Chronic hepatitis (CH) occurs commonly in dogs but is associated with a variable and largely unpredictable prognosis. p21, a cell-cycle inhibitor and marker of cellular senescence, is upregulated in human liver disease and is a better prognostic marker than histological or clinical...

Author(s)
Kortum, A. J.; Cloup, E. A.; Williams, T. L.; Constantino-Casas, F.; Watson, P. J.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 5, pp 1629-1636
Abstract

Background: Intestinal absorption of bile acids is mediated by the apical sodium-dependent bile acid transporter (ASBT). Fecal bile acid dysmetabolism has been reported in dogs with chronic inflammatory enteropathy (CIE). Objective: Characterization of ASBT distribution along the intestinal tract...

Author(s)
Giaretta, P. R.; Rech, R. R.; Guard, B. C.; Blake, A. B.; Blick, A. K.; Steiner, J. M.; Lidbury, J. A.; Cook, A. K.; Hanifeh, M.; Spillmann, T.; Kilpinen, S.; Syrjä, P.; Suchodolski, J. S.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 6, pp 1918-1926
Abstract

Background: The Janus Kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) pathways play important roles in the pathogenesis of diffuse large B cell lymphoma (DLBCL) in humans, and up-regulated STAT3 expression and activity are associated with worse clinical outcome in humans....

Author(s)
Assumpção, A. L. F. V.; Jark, P. C.; Hong, C. C.; Lu, Z.; Ruetten, H. M.; Heaton, C. M.; Pinkerton, M. E.; Pan, X.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 1, pp 361-369
Abstract

Pheochromocytoma is frequent in dogs and carries a guarded prognosis. Current histological criteria may not predict malignant behavior in dogs, similar to humans. In humans, characterization of tumors has been refined using the pheochromocytoma of the adrenal gland scaled score (PASS) and by ...

Author(s)
Zini, E.; Nolli, S.; Ferri, F.; Massari, F.; Gerardi, G.; Nicoli, S.; Romanelli, G.; Montinaro, V.; Trez, D.; Cavicchioli, L.; Ferro, S.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2019, 56, 3, pp 358-368

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