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Abstract

Background: Glomerular filtration rate (GFR) estimation is the gold standard for assessment of renal function, although the clinical utility of this test is unclear. Objectives: To describe the clinical utility of GFR estimation in dogs. Animals: Medical records of 132 dogs that had serum iohexol...

Author(s)
McKenna, M.; Pelligand, L.; Elliott, J.; Walker, D.; Jepson, R.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 1, pp 195-205
AbstractFull Text

Background: Nephropathies are among the most common diseases in dogs. Regular examination of the kidney function plays an important role for an adequate treatment scheme. The determination of the glomerular filtration rate (GFR) is seen as the gold standard in assessing the kidney status. Most of...

Author(s)
Mehl, J. N.; Lüpke, M.; Brenner, A. C.; Dziallas, P.; Wefstaedt, P.; Seifert, H.
Publisher
BioMed Central Ltd, London, UK
Citation
Acta Veterinaria Scandinavica, 2018, 60, 72, pp (6 November 2018)
Abstract

Background: Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required. Objective: To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum...

Author(s)
Pelander, L.; Häggström, J.; Larsson, A.; Syme, H.; Elliott, J.; Heiene, R.; Ljungvall, I.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 2, pp 630-639
Abstract

Background: Glomerular filtration rate (GFR) is the most sensitive indicator of initial renal function decline during chronic kidney disease (CKD), but conventional protocols for measuring GFR are labor-intensive and stressful for the dog. Objectives: To assess the diagnostic potential for...

Author(s)
Pocar, P.; Scarpa, P.; Berrini, A.; Cagnardi, P.; Rizzi, R.; Borromeo, V.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 5, pp 2105-2116
Abstract

Introduction: Acute kidney injury (AKI) leading to severe uremia is associated with high morbidity and mortality. Mannitol is an osmotic diuretic, widely used in the management of AKI, both as a bolus injection and as a constant rate infusion (CRI). Objectives: To determine the plasma concentration ...

Author(s)
Segev, G.; Stafford, C.; Kirby, J.; Cowgill, L. D.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 3, pp 1362-1367
Abstract

Ultrasound provides information on kidney morphology, but studies relating structural and functional abnormalities in chronic kidney disease (CKD) are lacking. The aim of this descriptive cross-sectional study was to compare individual kidney (IK) B-mode ultrasound abnormalities to IK glomerular ...

Author(s)
Mattei, C.; Pelander, L.; Hansson, K.; Uhlhorn, M.; Olsson, U.; Häggström, J.; Ljungvall, I.; Ley, C. J.
Publisher
Wiley, Boston, USA
Citation
Veterinary Radiology & Ultrasound, 2019, 60, 4, pp 432-446
AbstractFull Text

Early diagnosis of kidney disease continues to be a subject of intense interest. Direct measurement of glomerular filtration rate is too complicated for first-line practices; thus, indirect markers of renal function have also been evaluated. Creatinine, traditionally measured as a readout of renal...

Author(s)
Kovarikova, S.
Publisher
Czech Academy of Agricultural Sciences, Prague, Czech Republic
Citation
Veterinární Medicína, 2018, 63, 9, pp 395-412
Abstract

Background: Acute kidney injury (AKI) is a common problem in small-animal patients and carries a guarded prognosis with substantial morbidity and mortality, particularly in oligoanuric dogs. Fenoldopam, a selective dopamine agonist, has been shown to increase urine output in healthy dogs and cats;...

Author(s)
Kelly, K. L.; Drobatz, K. J.; Foster, J. D.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2016, 30, 5, pp 1655-1660
Abstract

Background: Serum creatinine and symmetric dimethylarginine (SDMA) are used as surrogate markers of glomerular filtration rate (GFR) in clinical practice. Data pertaining to the correlations between GFR, SDMA, and serum creatinine in client-owned dogs are limited. Objectives: To describe the...

Author(s)
McKenna, M.; Pelligand, L.; Elliott, J.; Cotter, D.; Jepson, R.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 1, pp 186-194
Abstract

MicroRNAs (miRNAs) are a group of small noncoding RNAs that act as regulators of posttranslational gene/protein expression and are known to play a key role in physiological and pathological processes. The objective of our study was to compare expression of miR-21 in renal tissue from dogs affected...

Author(s)
Clark, S. D.; Song WenPing; Cianciolo, R.; Lees, G.; Nabity, M.; Liu ShiGuang
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2019, 56, 1, pp 93-105

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