The autoagglutination test and direct and indirect Coombs, tests are used in the diagnosis of immune-mediated haemolytic anaemia (IMHA). The autoagglutination test is a test that the veterinary practitioner can easily implement in the clinic, but is only useful if autoagglutination is detected in...

The senile female dog suffering from rheumatoid arthritis was clinically and clinicopathologically examined. The articular lesions localized in the elbows, stifles, and the carpal and tarsal joints. The dog with clinical signs of arthritis developed draining nodular lesions in the involved joints....

Background: The Coombs' test, which detects immunoglobulin or complement on RBC surfaces, has long been the standard for laboratory confirmation of immune-mediated hemolytic anemia (IMHA), a common cause of hemolytic anemia in the dog. This test, however, suffers from relatively low sensitivity....

Immune-mediated hemolytic anemia leads to the premature removal of erythrocytes. It is a type 2 hypersensitivity reaction in which erythrocytes are covered by antibodies or complement and are phagocytized in the spleen or lysed within the blood vessels. It is considered of primary origin when the...

Background: Difficulties with the direct antiglobulin test (DAT) and its apparent lack of sensitivity and specificity for immune-mediated hemolytic anemia (IMHA) in dogs have raised skepticism regarding its diagnostic value. Objective: To compare different DATs and other hematologic parameters in ...

This study presented 48 cases of immune-mediated haemolytic anaemia (AIHA) in dogs. The causes of AIHA, diagnostic methods, erythrocyte degeneration, dependence on sex, breed and age as well as death rate were determined. The number of erythrocytes, leukocytes, thrombocytes, haematocrit (Ht) value...

Between June 2005 and December 2006 522 dogs were included in this study (group 1: 258 sick dogs suspicious for CGA, group 2: 264 clinically healthy dogs). Suspicious for CGA were dogs with clinical signs such as lethargy, fever, inappetence, pale mucous membranes, hemorrhage, joint pain,...

Despite the lack of evidence regarding a causal link between recent vaccination and development of immune mediated hemolytic anemia (IMHA) in dogs, a temporal association between them has been identified in some cases. The aim of this study was to evaluate: the presence of immunoglobulins (IgG and...

Classes of antibody bound to erythrocytes were determined using direct immunofluorescence (DIF) flow cytometry in 3 horses and 12 dogs with immune-mediated haemolytic anaemia (IMHA). Background levels of antibody binding were determined in samples from 12 horses and 12 dogs that were free of...

Background: Canine idiopathic immune-mediated hemolytic anemia (IMHA) is associated with a high mortality, especially in the 1st 2 weeks after diagnosis despite treatment. Objectives: To determine treatment outcome and identify prognostic variables in order to define areas of future research....