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Abstract

Background: The ideal method for monitoring trilostane therapy in dogs with hypercortisolism is still open to debate. Recently, determination of the pre-trilostane (prepill) cortisol concentration has been proposed to be more repeatable than either post-trilostane or post-ACTH cortisol. The aim of...

Author(s)
Boretti, F.; Musella, C.; Burkhardt, W.; Kuemmerle-Fraune, C.; Riond, B.; Reusch, C.; Sieber-Ruckstuhl, N.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2018, 14, 417, pp (27 December 2018)
Abstract

It is recommended that trilostane therapy of canine hyperadrenocorticism is monitored using an ACTH stimulation test, however this has never been validated. Three Cortisol concentrations (pre-trilostane, 3-hour posttrilostane and 1-hour post-ACTH stimulation) were compared to a clinical score...

Author(s)
Macfarlane, L.; Parkin, T.; Ramsey, I.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2016, 179, 23, pp 597
Abstract

Background: Results of ACTH stimulation test (ACTHst), pre- and post-trilostane serum cortisol concentrations (SCCs), urine concentration (urine-specific gravity [USG]), and urine cortisol : creatinine ratios (UCCRs) are common variables used to monitor trilostane treatment of dogs with...

Author(s)
Bermejo, C. A.; Alenza, D. P.; José, P. G. S.; Llauet, L.; Pérez-López, L.; Melián, C.; Feldman, E. C.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 4, pp 1413-1422
Abstract

OBJECTIVE: To evaluate use of cortisol concentration prior to ACTH stimulation (baseline) to monitor efficacy of twice-daily administration of trilostane to dogs with pituitary-dependent hyperadrenocorticism (PDH). DESIGN: Retrospective case series. ANIMALS: 22 dogs with PDH. PROCEDURES: The...

Author(s)
Woolcock, A. D.; Bugbee, A. C.; Creevy, K. E.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2016, 248, 7, pp 814-821
Abstract

Background: Glucocorticoids influence the synthesis and metabolism of catecholamines (epinephrine and norepinephrine) and metanephrines (metanephrine and normetanephrine). The aim of this study was to measure urinary catecholamines and metanephrines in dogs with hypercortisolism before and during ...

Author(s)
Sieber-Ruckstuhl, N.; Salesov, E.; Quante, S.; Riond, B.; Rentsch, K.; Hofmann-Lehmann, R.; Reusch, C.; Boretti, F.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2017, 13, 279, pp (4 September 2017)
Abstract

Background: There are no clear treatment guidelines for dogs with clinically well-regulated hyperadrenocorticism in which serum cortisol concentrations before and after an ACTH stimulation test performed 3-6 hours after trilostane administration are <2.0 µg/dL. Objective: To determine if serum cortisol concentrations measured before (Pre1)...

Author(s)
Midence, J. N.; Drobatz, K. J.; Hess, R. S.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2015, 29, 6, pp 1529-1533
Abstract

Many articles published in the past few years have contributed to a better understanding of the use of trilostane in dogs. Trilostane is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase, the enzyme essential for synthesis of Cortisol and all other steroids. Trilostane is reported to be...

Author(s)
Lemetayer, J.; Blois, S.
Publisher
Canadian Veterinary Medical Association, Ottawa, Canada
Citation
Canadian Veterinary Journal, 2018, 59, 4, pp 397-407
Abstract

Background: A high prevalence of cholestatic disease, including gallbladder mucocele (GBM), has been reported in dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH). Hypothesis/Objectives Differences exist in the clinical features of dogs with PDH and concurrent cholestatic ...

Author(s)
Kim, K. H.; Han, S. M.; Jeon, K. O.; Kim, H. T.; Li, Q.; Ryu, M. O.; Song, W. J.; Park, S. C.; Youn, H. Y.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2017, 31, 2, pp 335-342
Abstract

Objective - To determine whether a single measurement of cortisol concentration can be used to monitor dogs receiving trilostane for hyperadrenocorticism. Design - Controlled drug efficacy trial. Animals - 103 client-owned dogs. Procedures - Results of ACTH stimulation tests before and during ...

Author(s)
Cook, A. K.; Bond, K. G.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2010, 237, 7, pp 801-805
Abstract

Trilostane therapy, the treatment of choice for pituitary-dependent hyperadrenocorticism (HAC) in dogs, is monitored by assessing resolution of clinical signs and measuring adrenocortical reserve capacity with an ACTH-stimulation test. The aim of this prospective study was to evaluate agreement...

Author(s)
Boretti, F. S.; Holzthüm, J.; Reusch, C. E.; Sieber-Ruckstuhl, N. S.
Publisher
Gesellschaft Schweizer Tierärztinnen und Tierärzte GST, Bern, Switzerland
Citation
SAT, Schweizer Archiv für Tierheilkunde, 2016, 158, 9, pp 631-638

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