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Abstract

Hypocobalaminemia in dogs is most commonly associated with gastrointestinal disorders leading to impaired absorption and utilization of cobalamin. The objectives of this study were to compare serum cobalamin concentrations between dogs with leishmaniosis and clinically healthy dogs, and to assess...

Author(s)
Chatzis, M. K.; Kasabalis, D.; Steiner, J. M.; Saridomichelakis, M. N.; Suchodolski, J. S.; Xenoulis, P. G.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Comparative Immunology, Microbiology & Infectious Diseases, 2021, 78,
Abstract

The objective of this retrospective study was to evaluate serum cobalamin concentrations before and after oral cobalamin supplementation in dogs with low serum cobalamin concentrations and exocrine pancreatic insufficiency (EPI). Eighteen dogs with serum trypsin-like immunoreactivities between <1.0-2.7 μg/L (reference interval, 5.2-35 μg/L) and serum ...

Author(s)
Toresson, L.; Steiner, J. M.; Spodsberg, E.; Olmedal, G.; Suchodolski, J. S.; Lidbury, J. A.; Spillmann, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2021, 269,
Abstract

Disorders of cobalamin (vitamin B12) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism. Measurement of serum cobalamin concentration, often in combination with...

Author(s)
Kather, S.; Grützner, N.; Kook, P. H.; Dengler, F.; Heilmann, R. M.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 1, pp 13-28
Abstract

The aim of this study was to compare the efficacies of parenteral and oral cobalamin supplementation protocols in dogs with chronic enteropathies and low cobalamin concentrations. It was hypothesised that both treatments would increase serum cobalamin concentrations significantly. Fifty-three dogs...

Author(s)
Toresson, L.; Steiner, J. M.; Razdan, P.; Spodsberg, E.; Olmedal, G.; Suchodolski, J. S.; Spillmann, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2018, 232, pp 27-32
Abstract

OBJECTIVE: To evaluate the effects of withholding food on the results for measurements of serum concentrations of cobalamin, folate, canine pancreatic lipase immunoreactivity (cPLI), and canine trypsin-like immunoreactivity (cTLI) in healthy dogs. ANIMALS: 11 healthy employee- or student-owned ...

Author(s)
Saver, A. T.; Steiner, J. M.; Hetzel, S. J.; Lidbury, J. A.; Suchodolski, J. S.; Pritchard, J. C.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2021, 82, 5, pp 367-373
Abstract

Background: Cobalamin deficiency is commonly associated with chronic enteropathies (CE) in dogs and current treatment protocols recommend parenteral supplementation. In humans, several studies have reported equal efficacy of oral and parenteral cobalamin administration of cobalamin. Objectives: To...

Author(s)
Toresson, L.; Steiner, J. M.; Suchodolski, J. S.; Spillmann, T.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2016, 30, 1, pp 101-107
Abstract

Exocrine pancreatic insufficiency (EPI) in dogs is a gastrointestinal condition leading to a severe impairment of nutrient absorption. The disease is frequently associated with vitamin disturbances especially regarding cobalamin and folate. Dogs with EPI need daily expensive supportive treatment....

Author(s)
Soetart, N.; Rochel, D.; Drut, A.; Jaillardon, L.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 243, pp 15-20
Abstract

Background: Megaloblastic, nonregenerative anemia is a well-known consequence of cobalamin or folate deficiencies in humans but is not recognized in hypocobalaminemic or hypofolatemic dogs. Establishment of relationships between hypocobalaminemia or hypofolatemia and hematologic disease would...

Author(s)
Stanley, E.; Appleman, E.; Schlag, A.; Siegel, A.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 1, pp 106-113
Abstract

Hypocobalaminaemia is common in dogs and cats with exocrine pancreatic insufficiency and/or chronic enteropathy. While hypocobalaminaemia has been extensively studied, naturally-occurring serum hypercobalaminaemia (i.e. without supplementation) might be an underestimated finding in small animal...

Author(s)
Kather, S.; Sielski, L.; Dengler, F.; Jirasek, A.; Heilmann, R. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2020, 265,
Abstract

PICO question: In dogs with chronic enteropathy does treatment with oral cobalamin compared to parenteral cobalamin provide serum cobalamin levels greater than 270 ng/L? Clinical bottom line: The evidence provided by block randomised controlled clinical trials indicates that oral dosing of ...

Author(s)
McGinn, A.
Publisher
RCVS Knowledge, London, UK
Citation
Veterinary Evidence, 2019, 4, 3,

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