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Abstract

Disorders of cobalamin (vitamin B12) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism. Measurement of serum cobalamin concentration, often in combination with...

Author(s)
Kather, S.; Grützner, N.; Kook, P. H.; Dengler, F.; Heilmann, R. M.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 1, pp 13-28
Abstract

The aim of this study was to compare the efficacies of parenteral and oral cobalamin supplementation protocols in dogs with chronic enteropathies and low cobalamin concentrations. It was hypothesised that both treatments would increase serum cobalamin concentrations significantly. Fifty-three dogs...

Author(s)
Toresson, L.; Steiner, J. M.; Razdan, P.; Spodsberg, E.; Olmedal, G.; Suchodolski, J. S.; Spillmann, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2018, 232, pp 27-32
Abstract

Background: Megaloblastic, nonregenerative anemia is a well-known consequence of cobalamin or folate deficiencies in humans but is not recognized in hypocobalaminemic or hypofolatemic dogs. Establishment of relationships between hypocobalaminemia or hypofolatemia and hematologic disease would...

Author(s)
Stanley, E.; Appleman, E.; Schlag, A.; Siegel, A.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 1, pp 106-113
Abstract

Background: Cobalamin deficiency is commonly associated with chronic enteropathies (CE) in dogs and current treatment protocols recommend parenteral supplementation. In humans, several studies have reported equal efficacy of oral and parenteral cobalamin administration of cobalamin. Objectives: To...

Author(s)
Toresson, L.; Steiner, J. M.; Suchodolski, J. S.; Spillmann, T.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2016, 30, 1, pp 101-107
Abstract

Serum cobalamin and folate are often measured in cats and dogs as part of laboratory testing for intestinal disease, small intestinal dysbiosis, or exocrine pancreatic deficiency. We performed an analytical validation of human immunoassays for cobalamin and folate measurement (AIA-900 analyzer,...

Author(s)
McLeish, S. A.; Burt, K.; Papasouliotis, K.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2019, 31, 2, pp 164-174
Abstract

Cobalamin is a member of the B-group of vitamins and a cofactor for metabolic processes like nucleic acid synthesis, amino acid synthesis, and the citric acid cycle. Mammals are unable to synthesize cobalamin and therefore rely on adequate food intake. Cobalamin absorption is a complex process in...

Author(s)
Hanisch, F.; Toresson, L.; Spillmann, T.
Publisher
Schattauer GmbH, Stuttgart, Germany
Citation
Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 2018, 46, 5, pp 309-314
Abstract

Exocrine pancreatic insufficiency (EPI) in dogs is a gastrointestinal condition leading to a severe impairment of nutrient absorption. The disease is frequently associated with vitamin disturbances especially regarding cobalamin and folate. Dogs with EPI need daily expensive supportive treatment....

Author(s)
Soetart, N.; Rochel, D.; Drut, A.; Jaillardon, L.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 243, pp 15-20
Abstract

The objective of this study was to compare the effects of parenteral (PE) versus oral (PO) cobalamin supplementation on serum methylmalonic acid (MMA) and homocysteine (HCY) concentrations in dogs with hypocobalaminaemia. Thirty-six dogs with serum cobalamin concentrations below 285 ng/L (reference ...

Author(s)
Toresson, L.; Steiner, J. M.; Spodsberg, E.; Olmedal, G.; Suchodolski, J. S.; Lidbury, J. A.; Spillmann, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 243, pp 8-14
Abstract

OBJECTIVE: To evaluate the effects of storage conditions and duration on cobalamin concentration in serum samples from dogs and cats. DESIGN: Experiment. SAMPLE: Serum samples from 9 client-owned cats and 9 client-owned dogs. PROCEDURES: Serum harvested from freshly obtained blood samples was...

Author(s)
Kempf, J.; Melliger, R. H.; Reusch, C. E.; Kook, P. H.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2018, 252, 11, pp 1368-1371
Abstract

Background: Three Komondor dogs in a small family and 3 sporadic cases exhibited a constellation of signs that included juvenile-onset of failure-to-thrive, inappetence, vomiting and/or diarrhea, and weakness. In each we documented dyshematopoiesis, increased anion gap, methylmalonic...

Author(s)
Fyfe, J. C.; Hemker, S. L.; Frampton, A.; Raj, K.; Nagy, P. L.; Gibbon, K. J.; Giger, U.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2018, 14, 418, pp (27 December 2018)

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