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Abstract

Background: Glucocorticoids cause hypercoagulability, but it is unknown if they counteract clopidogrel's antiplatelet effects. Hypothesis/Objectives: Determine the effects of clopidogrel and prednisone on platelet function. Animals: Twenty-four healthy dogs. Methods: Double-blinded,...

Author(s)
Thomason, J.; Mooney, A. P.; Price, J. M.; Whittemore, J. C.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 3, pp 1198-1205
Abstract

Background: Dogs with protein-losing nephropathy (PLN) are treated with antiplatelet drugs for thromboprophylaxis but no standardized method exists to measure drug response. It is also unknown if clopidogrel metabolite concentrations [CM] differ between healthy and PLN dogs. Objectives: Assess...

Author(s)
Shropshire, S.; Johnson, T.; Olver, C.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 2, pp 710-718
Abstract

Background: Dogs with immune-mediated disease often receive glucocorticoids with clopidogrel, but ulcerogenic effects of current protocols are unknown. Hypothesis/Objectives: To compare gastrointestinal endoscopic findings among dogs administered clopidogrel, prednisone, and combination treatment....

Author(s)
Whittemore, J. C.; Mooney, A. P.; Price, J. M.; Thomason, J.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 6, pp 2618-2627
Abstract

Omeprazole is used concurrently with clopidogrel to reduce gastrointestinal adverse effects. In humans, the concurrent use of these two drugs can reduce the antiplatelet efficacy of clopidogrel. Our objective was to determine the effects of omeprazole and clopidogrel on platelet function in healthy ...

Author(s)
Thames, B. E.; Lovvorn, J.; Papich, M. G.; Wills, R.; Archer, T.; Mackin, A.; Thomason, J.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 2, pp 130-139
Abstract

Background: Platelet function testing may be warranted to assess response to aspirin and clopidogrel. Hypothesis/Objectives: To evaluate the effects of aspirin, clopidogrel, or combination therapy using 3 platelet function tests: Multiplate Analyzer (MP), Platelet Function Analyzer-200 (PFA), and...

Author(s)
Saati, S.; Abrams-Ogg, A. C. G.; Blois, S. L.; Wood, R. D.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 1, pp 111-118
Abstract

Congenital protein C deficiency is an important cause of thrombosis in humans but is not described in dogs. A 4-year-old Hungarian Vizsla was presented for investigation of acute onset of ascites. Computed tomography of the chest and abdomen and echocardiography confirmed a large thrombus within...

Author(s)
Kelly, D.; Juvet, F.; Moore, G.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 3, pp 1300-1303
Abstract

Whole blood impedance aggregometry is an important method to investigate platelet function disorders. Storage time is regarded as a main pre-analytical factor. The objective of the present study was to evaluate the influence of storage time of canine hirudin-anticoagulated blood on test results of...

Author(s)
Minde, J. W.; Mischke, R.
Publisher
Springer Science + Business Media, London, UK
Citation
Comparative Clinical Pathology, 2014, 23, 5, pp 1403-1407
Abstract

Objective - To determine pharmacodynamic and pharmacokinetic properties of clopidogrel and the metabolite SR 26334 in dogs. Animals - 9 mixed-breed dogs. Procedures - 8 dogs received clopidogrel (mean±SD 1.13±0.17 mg/kg, PO, q 24 h) for 3 days; 5 of these dogs subsequently received a lower dose of ...

Author(s)
Brainard, B. M.; Kleine, S. A.; Papich, M. G.; Budsberg, S. C.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2010, 71, 7, pp 822-830
Abstract

Objective: Mitral valve (MV) regurgitation due to degenerative MV disease is the leading cause of cardiac death in dogs. We carried out preliminary experiments to determine the feasibility and short-term effects of beating-heart MV repair using an expanded polytetrafluorethylene (ePTFE) chordal...

Author(s)
Borgarelli, M.; Lanz, O.; Pavlisko, N.; Abbott, J. A.; Menciotti, G.; Aherne, M.; Lahmers, S. M.; Lahmers, K. K.; Gammie, J. S.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2017, 19, 3, pp 256-267
Abstract

Two dogs with immune-mediated hemolytic anemia complicated with thromboembolism were presented. Both of the dogs were initially treated with immunosuppressive therapy in conjunction with dalteparin and clopidogrel. Although the immunosuppressive therapy was effective, peritoneal effusion due to...

Author(s)
Uchida, M.; Ohmi, A.; Fujiwara, R.; Fukushima, K.; Doi, A.; Azuma, K.; Tsujimoto, H.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2020, 82, 9, pp 1271-1276

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