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AbstractFull Text

BACKGROUND: Azathioprine is an immunosuppressive agent that is used in a variety of dermatologic, digestive and hematologic disorders in both humans and small animals. OBJECTIVES: The effects of long term Azathioprine administration on complete blood count, rate of CD4+ and CD8+ lymphocytes, serum...

Author(s)
Hassankhani, M.; Aldavood, S. J.; Khosravi, A.; Sasani, F.; Masoudifard, M.; Ansari, F.; Taheri, M.
Publisher
Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Citation
Iranian Journal of Veterinary Medicine, 2017, 11, 4, pp En361-En376, Pe38
Abstract

Background: In dogs, the effects of immunosuppressive medications on hemostasis are not well known. Hypothesis/Objectives: The objective was to determine the effects of immunosuppressive medications on primary and secondary hemostasis. Our hypothesis was that cyclosporine and prednisone would...

Author(s)
Thomason, J. M.; Archer, T. M.; Wills, R. W.; Mackin, A. J.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 4, pp 1325-1333
Abstract

A 1.5-year-old female Bernese mountain dog was presented for a bilateral acute episcleritis associated with cutaneous nodules and upper respiratory tract signs. The diagnosis of systemic reactive histiocytosis was based on clinical findings and confirmed by histopathological analysis of cutaneous...

Author(s)
Bourguet, A.; Robin, E.; Chahory, S.
Publisher
Elsevier Masson, Issy-les Moulineaux Cedex, France
Citation
Revue Vétérinaire Clinique, 2019, 54, 1, pp 29-35
Abstract

The objective of this report is to document a case of pneumatosis coli in an immunosuppressed dog successfully treated with supportive care that included hyperbaric oxygen. A 9 yr old, neutered male Maltese was presented for hematochezia of ∼36 h duration. The dog had a history of immune-mediated...

Author(s)
Fisk, A.; Allen-Durrance, A.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2019, 55, 4, pp e554-01
Abstract

A pharmacodynamic assay has been previously developed to monitor ciclosporin treatment in dogs by assessing inhibition of cytokine transcription after whole blood stimulation with 12-myristate 13-1 acetate and ionomycin (PMA/I). In this study, whole blood stimulation with either PMA/I or...

Author(s)
Dandrieux, J. R. S.; Narayanan, L.; Firestone, S.; Archer, T. M.; Mansfield, C. S.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2019, 5, 2, pp 199-205
Abstract

Three dogs who were presented with cutaneous lesions and had histopathologic findings consistent with pemphigus foliaceus were treated with injectable polysulfated glycosaminoglycan as an adjunctive to systemic immune-modulatory therapy. These patients were not adequately controlled with oral...

Author(s)
Simpson, A.; Rosychuck, R.; Schissler, J.; Souza, C.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2019, 55, 6, pp 318-322
Abstract

Background: The use of azathioprine (AZA) in dogs is limited by the development of hepatotoxicosis and cytopenias. Hypothesis and Objectives: To characterize the observed incidence, timing, and risk factors for AZA hepatotoxicosis in dogs treated clinically, and to determine the relationship...

Author(s)
Wallisch, K.; Trepanier, L. A.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2015, 29, 2, pp 513-518
Abstract

Objective - To compare treatment protocols for chronic enteropathy and concurrent protein-losing enteropathy that used prednisolone in conjunction with either azathioprine or chlorambucil in dogs. Design - Retrospective case series. Animals - 27 dogs. Procedures - All dogs had hypoalbuminemia...

Author(s)
Dandrieux, J. R. S.; Noble, P. J. M.; Scase, T. J.; Cripps, P. J.; German, A. J.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2013, 242, 12, pp 1705-1714
Abstract

The aim of this study was to compare the clinical activity index (CCECAI), age at diagnosis, serum albumin concentrations and outcome at various time points after diagnosis between a group of dogs treated with dietary management alone (food-responsive diarrhoea [FRD]), diet and antimicrobials...

Author(s)
Allenspach, K.; Culverwell, C.; Chan, D.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2016, 178, 15, pp 368
Abstract

Background: Mycophenolate mofetil (MMF) is a lymphocytotoxic immunosuppressive agent used in human and companion animal medicine for the treatment of immune-mediated disease. Mycophenolate mofetil is reported to have reduced myelotoxicity and hepatotoxicity when compared to azathioprine....

Author(s)
Ackermann, A. L.; May, E. R.; Frank, L. A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Dermatology, 2017, 28, 2, pp e44

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