Aeromonas veronii is one of the important pathogens causing motile Aeromonas septicemia (MAS) in aquaculture, leading to high fish mortality and severe economic losses. Live attenuated vaccines are considered to be an effective method to control bacterial infections and have been widely used in...

This study evaluated the vaccine-induced serological response after administering four commercial formulations containing Bovine Viral Diarrhea Virus (BVDV) type-1, BVDV-2, and Bovine Herpesvirus type 1 (BoHV-1) to young heifers with circulating maternal antibody titers. The study also determined...

The mucosal delivery route is considered ideal for immunization. However, induction of antigen-specific mucosal immunity is difficult due to the tolerogenic environment. Therefore, developing an immunogenic mucosal dendritic cell (DC)-targeting strategy is required. Herein, we investigated the...

West Nile virus (WNV) is a positive-sense single-stranded RNA virus belonging to the Flaviviridae family and is maintained in an enzootic cycle between avian hosts and mosquito vectors. Humans, horses and other mammals are susceptible to infection but are dead-end hosts due to a low viraemia. The...

TBK1 is an atypical IκB kinase family member with a set of functions. It is involved in congenital immunization and autophagy in mammals. In this study, we reported that grass carp TBK1 gene expression could be upregulated by bacterial infection. Overexpression of TBK1 could decrease the number of...

Despite the success of the widely used attenuated yellow fever (YF) vaccine, its global supply remains a substantial barrier to implementing vaccination campaigns in endemic regions and combating emerging epidemics. In A129 mice and rhesus macaques, we evaluated the immunogenicity and protective...

Dog vaccination is the key to controlling rabies in human populations. However, in countries like India, with large free-roaming dog populations, vaccination strategies that rely only on parenteral vaccines are unlikely to be either feasible or successful. Oral rabies vaccines could be used to...

The first generation of electronic devices for needle-free intradermal (id.) vaccination became available for the farm practice at the end of the 20^1st century. The wider uptake of this technology dates back to the last decade. The authors review all aspects of id. vaccination: the basics of skin...

Porcine epidemic diarrhea (PED) caused by porcine epidemic diarrhea virus (PEDV) is an acute and highly contagious enteric disease of pigs, which leads to high morbidity and mortality in the suckling piglets, thereby bringing huge economic losses to the global pig industry. Vaccination is currently ...

Induction of sterile immunity against sporozoite and liver stages of malaria is a long-standing aim in vaccine development. Genetically engineered, attenuated sporozoites were systematically evaluated in animal models. Murphy et al. present the first, promising clinical trial of early arresting...