West Nile virus (WNV) is a positive-sense single-stranded RNA virus belonging to the Flaviviridae family and is maintained in an enzootic cycle between avian hosts and mosquito vectors. Humans, horses and other mammals are susceptible to infection but are dead-end hosts due to a low viraemia. The...

Despite the success of the widely used attenuated yellow fever (YF) vaccine, its global supply remains a substantial barrier to implementing vaccination campaigns in endemic regions and combating emerging epidemics. In A129 mice and rhesus macaques, we evaluated the immunogenicity and protective...

Dog vaccination is the key to controlling rabies in human populations. However, in countries like India, with large free-roaming dog populations, vaccination strategies that rely only on parenteral vaccines are unlikely to be either feasible or successful. Oral rabies vaccines could be used to...

Porcine epidemic diarrhea (PED) caused by porcine epidemic diarrhea virus (PEDV) is an acute and highly contagious enteric disease of pigs, which leads to high morbidity and mortality in the suckling piglets, thereby bringing huge economic losses to the global pig industry. Vaccination is currently ...

Adintrevimab is a human immunoglobulin G1 monoclonal antibody engineered to have broad neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and other SARS-like coronaviruses with pandemic potential. In both Syrian golden hamster and rhesus macaque models,...

A 5-year-old female english setter was presented for a rapidly progressive proteinuric acute kidney injury (AKI). During hospitalization, worsening of azotemia and development of oliguria and hyperkalemia warranted a hemodiafiltration session. Renal biopsies and histopathology revealed severe renal ...

Adenovirus vectors have developed from initial gene therapy tools to more mature vaccine vectors. Adenovirus vector vaccinesinduce strong humoral and cellular immune responses in hosts. Ebola vaccines and SARS-CoV-2 vaccines based on adenovirus vectors have been approved for marketing. In addition, ...

Brucellosis is a chronic zoonotic bacterial infectious disease caused by Brucella infection. Its epidemic range is almost all over the world, and it is highly contagious, which seriously affects public health and animal husbandry. Therefore, The key of eliminating brucellosis is to control the...

The last two decades has witnessed a disruption of socio-economic, security and political foundation worldwide due to surging of health events arising at the ecosystem, animal and human interface. The unprecedent magnitude of these events has led to the adoption of One Health approach. Several...

This article provides a comprehensive overview of the current state of diagnostics and treatment options for canine heartworm disease. It first discusses the importance of early detection and diagnosis of heartworm infection, as well as the limitations and challenges of currently available...