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Abstract

The efficacy of moxidectin, a new endectocide against natural nematode infections, was evaluated. 25 calves were divided into 2 groups of 8 calves each and a 3rd group of 9 calves served as controls. Moxidectin was administered sc to 2 groups (I, 0.2 mg/kg bwt; II, 0.3 mg/kg bwt) and the 3rd group...

Author(s)
Ranjan, S.; Trudeau, C.; Prichard, R. K.; Kutzleben, R. von; Carrier, D.
Citation
Veterinary Parasitology, 1992, 41, 3-4, pp 227-231
Abstract

The efficacy, mode of action, pharmacokinetics, and metabolism of ivermectin, netobimin, closantel, triclabendazole and clorsulon are reviewed. Potential control of Fasciola hepatica in livestock is significantly improved with 4 of the new anthelmintics being fasciolicidal. Recent findings on the...

Author(s)
Prichard, R. K.
Publisher
Australian Academy of Science, Canberra, ACT 2601, Australia
Citation
Parasitology - Quo vadit? Proceedings of the 6th International Congress of Parasitology, 24-29 August 1986, Brisbane, Queensland, Australia., 1986, pp 473-482
Abstract

This review deals firstly with the administration and absorption of anthelmintics and the comparative biochemistry of host and parasite before concentrating on those anthelmintics used in Australia, especially their efficacy, pharmacokinetic behaviour, toxicity and teratogenicity, and mode of...

Author(s)
Prichard, R. K.
Publisher
Division of Animal Health, CSIRO, Australia
Citation
The epidemiology and control of gastrointestinal parasites of cattle in Australia., 1983, pp 73-90
Abstract

The metabolism of albendazole (ABZ), albendazole sulfoxide (ABZSO) and albendazole sulfone (ABZSO2) by ruminal, abomasal and ileal fluids of sheep and cattle was investigated under anaerobic conditions in vitro. None of the compounds was metabolically changed by incubation with abomasal fluids of...

Author(s)
Lanusse, C. E.; Nare, B.; Gascon, L. H.; Prichard, R. K.
Citation
Xenobiotica, 1992, 22, 4, pp 419-426
Abstract

Eight Holstein steers (150-180 kg) were implanted with permanent cannulae in the rumen, abomasum and ileum. After recovery, the animals were treated orally with a suspension of netobimin zwitterion (NTB; 400 mg/ml) at 20 mg/kg. Jugular blood and ruminal, abomasal and ileal fluid samples were taken...

Author(s)
Lanusse, C. E.; Gascon, L. H.; Prichard, R. K.
Citation
Journal of Veterinary Pharmacology and Therapeutics, 1993, 16, 1, pp 38-47
Abstract

The pharmacokinetics and gastrointestinal distribution of morantel tartrate release from a sustained release trilaminate bolus (Paratect Flex) in cattle were investigated over a 98-day period post-treatment. Six Holstein calves (125-150 kg) had permanent indwelling fistulae surgically inserted into ...

Author(s)
Lanusse, C. E.; Gascon, L. H.; Ranjan, S.; Prichard, R. K.
Citation
Journal of Veterinary Pharmacology and Therapeutics, 1992, 15, 2, pp 117-123
Abstract

Anthelmintics, which remain the principal means for the prevention and control of subclinical and clinical ostertagiasis are reviewed under the headings: available anthelmintics (ivermectin, albendazole, fenbendazole, oxfendazole, thiabendazole, levamisole, morantel tartrate, phenothiazine,...

Author(s)
Prichard, R. K.; Ranjan, S.
Citation
Veterinary Parasitology, 1993, 46, 1-4, pp 113-120
Abstract

The clinical pharmacokinetics and metabolic patterns for the therapeutically more important benzimidazole compounds in ruminants are reviewed. The following topics are considered: benzimidazole chemistry (synthesis and classification, and structure-activity relationship), absorption (influence of...

Author(s)
Lanusse, C. E.; Prichard, R. K.
Citation
Drug Metabolism Reviews, 1993, 25, 3, pp 235-279
Abstract

The effects of methimazole (MTZ) on the pharmacokinetic behaviour of netobimin (NTB) and its albendazole (ABZ) metabolites were studied in 8 Holstein Friesian bull calves. NTB trisamine salt solution was given by subcutaneous (12.5 mg/kg) and oral (20 mg/kg) routes, either alone or co-administered...

Author(s)
Lanusse, C. E.; Prichard, R. K.
Citation
Xenobiotica, 1992, 22, 1, pp 115-123
Abstract

Pharmacokinetic profiles of the major metabolities of netobimin were investigated in calves after oral administration of the compound (20 mg/kg) as a zwitterion suspension and trisamine salt solution in a two-way cross-over design. Blood samples were taken serially over a 72 h period and plasma was ...

Author(s)
Lanusse, C. E.; Trudeau, C.; Ranjan, S.; Prichard, R. K.
Citation
Journal of Veterinary Pharmacology and Therapeutics, 1991, 14, 1, pp 101-108

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