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Veterinary information to support practice, based on evidence and continuing education

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Studies in laboratory animals showed closantel to be well tolerated. Repeated oral dosing was without major effect up to 40 mg/kg in rats and dogs. In sheep, repeated dosing at 10 and 40 mg/kg orally and at 5 and 20 mg/kg intramuscularly every 4 weeks over 40 weeks showed an acceptable safety...

Cauteren, H. van; Vanderbenghe, J.; Hérin, V.; Vanparys, P.; Marsboom, R.
Drug and Chemical Toxicology, 1985, 8, 3, pp 101-123