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Veterinary information to support practice, based on evidence and continuing education

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Abstract

A series of 28 controlled anthelmintic studies, involving 634 cattle, was conducted throughout North America and Europe to evaluate the efficacy of doramectin against a broad range of gastrointestinal parasitic nematode species and lungworms in naturally and experimentally infected animals. Within...

Author(s)
Jones, R. M.; Logan, N. B.; Weatherley, A. J.; Little, A. S.; Smothers, C. D.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 27-37
Abstract

The pharmacokinetics of doramectin, a novel avermectin, were evaluated following parenteral administration to calves in a range of oil-based formulations in an attempt to optimize the formulation. Therapeutic and persistent efficacies against Cooperia oncophora in cattle were also evaluated. This...

Author(s)
Wicks, S. R.; Kaye, B.; Weatherley, A. J.; Lewis, D.; Davison, E.; Gibson, S. P.; Smith, D. G.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 17-26
Abstract

Two studies were performed to investigate the efficacy of doramectin in the prevention of infection with Ostertagia ostertagi and Cooperia oncophora in grazing calves. In each study 24 parasite-naive calves were randomly allotted to 2 equal groups and treated with either doramectin at 200 µg/kg or...

Author(s)
Vercruysse, J.; Dorny, P.; Hong, C.; Harris, T. J.; Hammet, N. C.; Smith, D. G.; Weatherley, A. J.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 51-59
Abstract

The efficacy of a new anthelmintic sustained release bolus for cattle, the MSRT (Morantel Sustained Release Trilaminate) was evaluated in the prevention of parasitic gastroenteritis throughout the first season at pasture. Sixty Normandy cattle were divided into two equal groups set stocked on two...

Author(s)
Weatherley, A. J.; Grimshaw, W. T. R.; Shanks, D. J.; Charbonnier, J. L.; Jones, R. M.
Citation
Revue de Médecine Vétérinaire, 1989, 140, 11, pp 1023-1027
Abstract

Two studies were conducted in Idaho and North Carolina, USA, to evaluate the persistent efficacy of doramectin injectable solution against experimental challenge with infective larvae of Ostertagia ostertagi. In both studies, 4 groups of 10 randomly-assigned calves, negative for...

Author(s)
Conder, G. A.; Cruthers, L. R.; Slone, R. L.; Johnson, E. G.; Zimmerman, G. L.; Zimmerman, L. A.; Shively, J. E.; Logan, N. B.; Weatherley, A. J.
Citation
Veterinary Parasitology, 1997, 72, 1, pp 9-13
Abstract

A total of 40 cattle in Germany harbouring naturally acquired infections of gastrointestinal nematodes, including Ostertagia spp., Oesophagostomum spp. Cooperia spp., Haemonchus spp., Nematodirus spp. and Trichuris spp., were allocated to a treated or a control group (20 animals/group), and 100...

Author(s)
Mehlhorn, H.; Jones, H. L.; Weatherley, A. J.; Schumacher, B.
Citation
Parasitology Research, 1993, 79, 7, pp 603-607
Abstract

A novel intraruminal bolus developed for the sustained delivery of the anthelmintic morantel tartrate was evaluated in the seasonal control of parasitic gastroenteritis in first season grazing calves. The morantel sustained release trilaminate is a laminated sheet consisting of a central lamina of...

Author(s)
Grimshaw, W. T. R.; Weatherley, A. J.; Jones, R. M.
Citation
Veterinary Record, 1989, 124, 17, pp 453-456
Abstract

Doramectin, 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a, was selected as the best of a series of novel avermectins prepared by mutational biosynthesis. The primary evaluation of its in vivo antiparasitic activity was carried out using a rat Trichostrongylus colubriformis model...

Author(s)
Goudie, A. C.; Evans, N. A.; Gration, K. A. F.; Bishop, B. F.; Gibson, S. P.; Holdom, K. S.; Kaye, B.; Wicks, S. R.; Lewis, D.; Weatherley, A. J.; Bruce, C. I.; Herbert, A.; Seymour, D. J.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 5-15
Abstract

Three studies were conducted involving cattle exposed to experimental nematode infections. These studies were designed to investigate the prophylactic activity of a single s.c. treatment of doramectin at 200 µg/kg bwt against infections of Ostertagia ostertagi, Cooperia oncophora and Dictyocaulus...

Author(s)
Weatherley, A. J.; Hong, C.; Harris, T. J.; Smith, D. G.; Hammet, N. C.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 45-50

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