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Abstract

East Coast fever, babesiosis, and anaplasmosis are the major tick-borne diseases affecting cattle productivity in Uganda. The emergence of acaricide-resistant ticks is suspected to have caused a rise in hemoparasites. This study sought to detect and characterize hemoparasites among farms in...

Author(s)
Tayebwa, D. S.; Vudriko, P.; Tuvshintulga, B.; Guswanto, A.; Nugraha, A. B.; Gantuya, S.; Batiha, G. E. S.; Musinguzi, S. P.; Komugisha, M.; Bbira, J. S.; Okwee-Acai, J.; Tweyongyere, R.; Wampande, E. M.; Byaruhanga, J.; Moumouni, P. F. A.; Thillaiampalam Sivakumar; Yokoyama, N.; Igarashi, I.
Publisher
Elsevier GmbH, München, Germany
Citation
Ticks and Tick-borne Diseases, 2018, 9, 6, pp 1475-1483
Abstract

The treatment of bovine and equine piroplasmosis is limited to diminazene aceturate (DA) and imidocarb dipropionate. To address this challenge, we need to explore novel drug compounds and targets. Topoisomerases are potential drug targets because they play a vital role in solving topological errors ...

Author(s)
Tayebwa, D. S.; Bumduuren Tuvshintulga; Guswanto, A.; Nugraha, A. B.; Batiha, G. E.; Gantuya, S.; Rizk, M. A.; Vudriko, P.; Thillaiampalam Sivakumar; Yokoyama, N.; Igarashi, I.
Publisher
Elsevier GmbH, München, Germany
Citation
Ticks and Tick-borne Diseases, 2018, 9, 5, pp 1192-1201
Abstract

There is an innovative approach to discovering and developing novel potent and safe anti-Babesia and anti-Theileria agents for the control of animal piroplasmosis. Large-scale screening of 400 compounds from a Malaria Box (a treasure trove of 400 diverse compounds with antimalarial activity has...

Author(s)
Rizk, M. A.; El-Sayed, S. A. E.; El-Khodery, S.; Yokoyama, N.; Igarashi, I.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2019, 274, pp 108895
Abstract

Throughout the world, infections with the Babesia and Theileria parasites often result in economically significant clinical disease in cattle. We conducted a longitudinal survey of Babesia and Theileria infections in cattle from the Polonnaruwa (n=75; dry zone) and Nuwara Eliya (n=161; wet zone)...

Author(s)
Sivakumar, T.; Kothalawala, H.; Weerasooriya, G.; Silva, S. S. P.; Puvanendiran, S.; Munkhjargal, T.; Igarashi, I.; Yokoyama, N.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology: Regional Studies and Reports, 2016, 6, pp 20-27
Abstract

Hemoprotozoan parasites are responsible for significant economic losses in cattle. We screened Sri Lankan cattle populations for the presence of Babesia bovis, Babesia bigemina, Theileria annulata, and Theileria orientalis, using species-specific PCR assays. Out of 316 samples collected from...

Author(s)
Sivakumar, T.; Kothalawala, H.; Abeyratne, S. A. E.; Vimalakumar, S. C.; Meewewa, A. S.; Hadirampela, D. T.; Puvirajan, T.; Sukumar, S.; Kuleswarakumar, K.; Chandrasiri, A. D. N.; Igarashi, I.; Yokoyama, N.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Parasitology, 2012, 190, 1/2, pp 263-267
Abstract

Allicin is an active ingredient of garlic that has antibacterial, antifungal, antiviral, and antiprotozoal activity. However, the inhibitory effects of allicin on Babesia parasites have not yet been examined. In the present study, allicin was tested as a potent inhibitor against the in vitro growth ...

Author(s)
Salama, A. A.; Aboulaila, M.; Terkawi, M. A.; Mousa, A.; El-Sify, A.; Allaam, M.; Zaghawa, A.; Yokoyama, N.; Igarashi, I.
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Parasitology Research, 2014, 113, 1, pp 275-283
Abstract

Fusidic acid known to has antibacterial, antifungal, and antimalarial activities. Fusidic acid blocks translation elongation factor G gene in Plasmodium falciparum. In the present study, the inhibitory effects of fusidic acid on the in vitro growth of bovine and equine Babesia parasites were...

Author(s)
Salama, A. A.; AbouLaila, M.; Moussa, A. A.; Nayel, M. A.; El-Sify, A.; Terkawi, M. A.; Hassan, H. Y.; Yokoyama, N.; Igarashi, I.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Parasitology, 2013, 191, 1/2, pp 1-10

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