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Abstract

The role of foot-and-mouth disease virus (FMDV) persistently infected ruminants in initiating new outbreaks remains controversial, and the perceived threat posed by such animals hinders international trade in FMD-endemic countries. In this study we report longitudinal analyses of genetic and...

Author(s)
Biswal, J. K.; Rajeev Ranjan; Saravanan Subramaniam; Mohapatra, J. K.; Sanjay Patidar; Sharma, M. K.; Bertram, M. R.; Brito, B.; Rodriguez, L. L.; Bramhadev Pattnaik; Arzt, J.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 6, pp e0214832
Abstract

Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease of cloven-hoofed animals, including domestic and wild host species. During recent FMD outbreaks in India, spontaneous abortions were reported amongst FMD-affected and asymptomatic cows. The current study...

Author(s)
Rajeev Ranjan; Biswal, J. K.; Saravanan Subramaniam; Singh, K. P.; Stenfeldt, C.; Rodriguez, L. L.; Bramhadev Pattnaik; Arzt, J.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2016, 11, 12, pp e0167163
Abstract

Background: Understanding the mechanisms of attenuation and virulence of foot-and-mouth disease virus (FMDV) in the natural host species is critical for development of next-generation countermeasures such as live-attenuated vaccines. Functional genomics analyses of FMDV have identified few...

Author(s)
Arzt, J.; Pacheco, J. M.; Stenfeldt, C.; Rodriguez, L. L.
Publisher
BioMed Central Ltd, London, UK
Citation
Virology Journal, 2017, 14, 89, pp (2 May 2017)
Abstract

We report the laboratory analysis of 125 clinical samples from suspected cases of foot-and-mouth disease (FMD) in cattle and Asian buffalo collected in Pakistan between 2008 and 2012. Of these samples, 89 were found to contain viral RNA by rRT-PCR, of which 88 were also found to contain infectious...

Author(s)
Ahmed, Z.; Pauszek, S. J.; Ludi, A.; LaRocco, M.; Khan, E. U. H.; Afzal, M.; Arshed, M. J.; Farooq, U.; Arzt, J.; Bertram, M.; Brito, B.; Naeem, K.; Abubakar, M.; Rodriguez, L. L.
Publisher
Wiley, Berlin, Germany
Citation
Transboundary and Emerging Diseases, 2018, 65, 2, pp 534-546
Abstract

Tissues obtained post-mortem from cattle persistently infected with foot-and-mouth disease virus (FMDV) were analyzed to characterize the tissue-specific localization of FMDV and partial transcriptome profiles for selected immunoregulatory cytokines. Analysis of 28 distinct anatomic sites from 21...

Author(s)
Pacheco, J. M.; Smoliga, G. R.; O'Donnell, V.; Brito, B. P.; Stenfeldt, C.; Rodriguez, L. L.; Arzt, J.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2015, 10, 5, pp e0125698
Abstract

The goal of this study was to identify the primary sites of replication of foot-and-mouth disease virus (FMDV) in cattle subsequent to aerogenous inoculation. A novel aerosol inoculation method was developed to simulate natural, airborne transmission and thereby allow the identification of early...

Author(s)
Pacheco, J. M.; Arzt, J.; Rodriguez, L. L.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Journal, 2010, 183, 1, pp 46-53
Abstract

Replication-defective recombinant adenovirus 5 (rAd5) vectors carrying foot-and-mouth disease virus (FMDV) transgenes elicit a robust immune response to FMDV challenge in cattle; however mechanistic functions of vaccine function are incompletely understood. Recent efforts addressing critical...

Author(s)
Montiel, N. A.; Smoliga, G.; Arzt, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Immunology and Immunopathology, 2013, 151, 1/2, pp 37-48
Abstract

To characterize the early events of foot-and-mouth disease virus (FMDV) infection in cattle subsequent to simulated natural exposure, 16 steers were aerosol inoculated with FMDV and euthanized at various times. Samples were collected from each steer antemortem (serum, nasal swabs, and oral swabs)...

Author(s)
Arzt, J.; Pacheco, J. M.; Rodriguez, L. L.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2010, 47, 6, pp 1048-1063
Abstract

Immunohistochemical (IHC) and fluorescent antibody (FA) techniques were optimized for the detection of Foot-and-mouth disease virus (FMDV) structural and nonstructural proteins in frozen and paraformaldehyde-fixed, paraffin-embedded (PFPE) tissues of bovine and porcine origin. Immunohistochemical...

Author(s)
Arzt, J.; Gregg, D. A.; Clavijo, A.; Rodriguez, L. L.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2009, 21, 6, pp 779-792

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