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Abstract

The identification of copy number variations (CNVs) allow us to explore genomic polymorphisms. In recent years, significant progress in understanding CNVs has been made in studies of human and animals, however, association and expression studies of CNVs are still in the early stage. It was...

Author(s)
Yang MingJuan; Lv JingQiao; Zhang LiangZhi; Li MingXun; Zhou Yang; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2017, 7, 1, pp 46599
Abstract

Background: Copy number variations (CNVs) are structural variants consisting of large-scale insertions and deletions of genomic fragments. Exploring CNVs and estimating their effects on phenotypes are useful for genome selection but remain challenging in the livestock. Results: We identified 1043...

Author(s)
Liu Mei; Fang LingZhao; Liu ShuLi; Pan, M. G.; Seroussi, E.; Cole, J. B.; Ma Li; Chen Hong; Liu, G. E.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2019, 20, 181, pp (7 March 2019)
Abstract

Acyl-CoA dehydrogenase, very long chain (ACADVL), encoding ACADVL protein, targets the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway and plays an important role in body metabolism and oxidation of long chain fatty acid...

Author(s)
Zhang SiHuan; Dang YongLong; Zhang QingFeng; Qin QiaoMei; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2015, 559, 2, pp 184-188
Abstract

Background: Copy number variations (CNVs) are a main source of genomic structural variations underlying animal evolution and production traits. Here, with one pure-blooded Angus bull as reference, we describe a genome-wide analysis of CNVs based on comparative genomic hybridization arrays in 29...

Author(s)
Zhang LiangZhi; Jia ShanGang; Yang MingJuan; Xu Yao; Li, C. J.; Sun JiaJie; Huang YongZhen; Lan XianYong; Lei ChuZhao; Zhou Yang; Zhang ChunLei; Zhao Xin; Chen Hong
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2014, 15, 480, pp (17 June 2014)
Abstract

The paired box 7 (Pax7) gene encoding for the transcription factor can regulate the conversion of stem cells into myogenic cells and participate in the development and regeneration of skeletal muscle. The aims of this study were to detect variations of the Pax7 gene by DNA pool sequencing and...

Author(s)
Xu Yao; Zhou Yang; Wang Ning; Lan XianYong; Zhang ChunLei; Lei ChuZhao; Chen Hong
Publisher
NRC Research Press, Ottawa, Canada
Citation
Genome, 2013, 56, 1, pp 9-15
Abstract

As an adaptor protein, apart from potentiating Janus kinase 2 (JAK2) activation and promoting the insulin signaling pathway, Src homology 2 B 2 (SH2B2) indirectly takes part in the regulation of glucose uptake through the c-Cb1/CAP/TC10 pathway, which can in turn affect growth. In this study, we...

Author(s)
Yang MingJuan; Fu JunHui; Lan XianYong; Sun YuJia; Lei ChuZhao; Zhang ChunLei; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2013, 528, 2, pp 314-319
Abstract

Zinc-a2-glycoprotien (AZGP1) involved in lipid metabolism and associated with adipose tissue atrophy in cachexia. And it also related to sperm motility and in turn fertilization. To ascertain whether there were mutations in the bovine AZGP1 gene, this study investigated variation of the AZGP1 gene...

Author(s)
Zhang Bao; Guo YiKun; Li ShengBin; Zhang LiangZhi; Lan XianYong; Hu ShenRong; Chen Hong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2012, 39, 12, pp 10475-10479
Abstract

Apolipoprotein A-II (APOA2) is one of the major constituents of high-density lipoprotein and plays a critical role in lipid metabolism and obesity. However, similar research for the bovine APOA2 gene is lacking. In this study, polymorphisms of the bovine APOA2 gene and its promoter region were...

Author(s)
Zhou Yang; Li CaiXia; Cai HanFang; Xu Yao; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2013, 531, 2, pp 288-293
AbstractFull Text

Fat-inducing transcript (FIT) are endoplasmic reticulum-resident membrane proteins that induce lipid droplet accumulation. It plays a crucial role in the fundamental process of storing fat. In this study, applying the PCR-SSCP and DNA sequencing methods, polymorphism of the FIT gene were detected....

Author(s)
Sun JiaJie; Zhang ChunLei; Fang XingTang; Lei ChuZhao; Lan XianYong; Chen Hong
Publisher
Polish Academy of Sciences, Institute of Genetics and Animal Breeding, Jastrzebiec, Poland
Citation
Animal Science Papers and Reports, 2011, 29, 2, pp 99-107
Abstract

Genetic polymorphism of the prolactin receptor (PRLR) gene was detected by PCR-SSCP and DNA sequencing methods in 665 individuals from five Chinese cattle breeds. The results showed that at the P1 locus, three observed genotypes (AA, AB and BB), two linked SNPs (G1267A and T1268C), and one missense ...

Author(s)
LüAiJun; Hu XiuCai; Chen Hong; Dong YongJun; Pang YongHong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2011, 38, 1, pp 261-266

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