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Abstract

Molecular typing techniques are useful in understanding tuberculosis epidemiology; yet, they have been under-utilised at the human-animal interface in Nigeria. Sixty-four Mycobacterium tuberculosis complex (MTBC) isolates including 42 M. tuberculosis, 13 M. bovis and nine M. africanum obtained from ...

Author(s)
Adesokan, H. K.; Streicher, E. M.; Helden, P. D. van; Warren, R. M.; Cadmus, S. I. B.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 2, pp e0211637
Abstract

The QuantiFERON®-TB Gold (QFT) stimulation platform for cytokine release is a novel approach for diagnosis of bovine tuberculosis in wildlife species. Plasma interferon gamma (IFN-γ) is routinely measured to detect immune sensitization to Mycobacterium bovis. However, the cytokine interferon...

Author(s)
Bernitz, N.; Kerr, T. J.; Goosen, W. J.; Clarke, C.; Higgitt, R.; Roos, E. O.; Cooper, D. V.; Warren, R. M.; Helden, P. D. van; Parsons, S. D. C.; Miller, M. A.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Preventive Veterinary Medicine, 2019, 169, pp 104700
Abstract

Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is endemic in Kruger National Park, South Africa, home to the largest population of white rhinoceros (Ceratotherium simum) in the world. In 2016, the first cases of naturally occurring bTB were reported in white rhinoceros; however, there is ...

Author(s)
Chileshe, J.; Goosen, W. J.; Buss, P. E.; Helden, P. D. van; Warren, R.; Parsons, S. D. C.; Miller, M. A.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2019, 31, 4, pp 531-536
Abstract

African buffaloes (Syncerus caffer) are wildlife maintenance hosts of Mycobacterium bovis, the cause of bovine tuberculosis. Consequently, M. bovis infected buffaloes pose a transmission risk for cattle and other wildlife species. Previously, a modification to the Qiagen QuantiFERON®-TB Gold (QFT)...

Author(s)
Bernitz, N.; Clarke, C.; Roos, E. O.; Goosen, W. J.; Cooper, D.; Helden, P. D. van; Parsons, S. D. C.; Miller, M. A.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 196, pp 48-52
Abstract

The diagnosis of Mycobacterium bovis (M. bovis) infection in African buffaloes (Syncerus caffer) relies on detection of the cell-mediated immune response to M. bovis antigens using the single comparative intradermal tuberculin test (SCITT) or interferon gamma release assays (IGRAs). The aim of the...

Author(s)
Bernitz, N.; Goosen, W. J.; Clarke, C.; Kerr, T. J.; Higgitt, R.; Roos, E. O.; Cooper, D. V.; Warren, R. M.; Helden, P. D. van; Parsons, S. D. C.; Miller, M. A.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 204, pp 40-43
Abstract

The most widely used ante-mortem diagnostic tests for tuberculosis in cattle are the tuberculin skin test and the interferon-gamma (IFN-γ) release assay, both of which measure cell-mediated immune responses to Mycobacterium bovis infection. However, limitations in the performance of these tests...

Author(s)
Parsons, S. D. C.; McGill, K.; Doyle, M. B.; Goosen, W. J.; Helden, P. D. van; Gormley, E.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2016, 11, 5, pp e0155440
Abstract

Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis), has been reported in many species including suids. Wild boar are important maintenance hosts of the infection with other suids, that is domestic and feral pigs, being important spillover hosts in the Eurasian ecosystem and in...

Author(s)
Roos, E. O.; Olea-Popelka, F.; Buss, P.; Klerk-Lorist, L. M. de; Cooper, D.; Helden, P. D. van; Parsons, S. D. C.; Miller, M. A.
Publisher
Wiley, Berlin, Germany
Citation
Transboundary and Emerging Diseases, 2018, 65, 5, pp 1182-1189
Abstract

Effective disease management of wildlife relies on the strategic application of ante-mortem diagnostic tests for early identification and removal of M. bovis-infected animals. To improve diagnostic performance, interferon-gamma release assays (IGRAs) are often used in conjunction with the...

Author(s)
Clarke, C.; Cooper, D.; Goosen, W. J.; McFadyen, R.; Warren, R. M.; Helden, P. D. van; Parsons, S. D. C.; Miller, M. A.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 201, pp 12-15
Abstract

Bovine tuberculosis (bTB) is endemic in several areas of South Africa and has been reported in multiple species, including common warthogs (Phacochoerus africanus). Limited diagnostic tests and disease control programs exist for African wildlife. Thus, there is a need to develop techniques for bTB...

Author(s)
Roos, E. O.; Olea-Popelka, F.; Buss, P.; Klerk-Lorist, L. M. de; Cooper, D.; Warren, R. M.; Helden, P. D. van; Parsons, S. D. C.; Miller, M. A.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 201, pp 43-48
Abstract

Background: Bovine tuberculosis (bTB) caused by Mycobacterium bovis has previously been diagnosed in warthogs and infection can be highly prevalent (>30%) in endemic areas. Thus, warthogs could potentially be an important species to consider as sentinels for disease surveillance. However,...

Author(s)
Roos, E. O.; Olea-Popelka, F.; Buss, P.; Hausler, G. A.; Warren, R.; Helden, P. D. van; Parsons, S. D. C.; Klerk-Lorist, L. M. de; Miller, M. A.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2018, 14, 360, pp (20 November 2018)

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