For 19 F & M disease viruses (16 cattle strains representing all seven types) the approximate minimum infective dose (MID) expressed in bovine ID₅₀ units, varied: from 0.01 to 2.0 units for tongue route of inoculation in cattle: from 0.01 to 6.0 units for i/p inoculation in mice; and from 0.002 to...

Complement-fixing antibody to rinderpest virus was demonstrated in heat-inactivated cattle sera, using an extract of rinderpest-infected bovine lymph nodes as antigen, increasing concentrations of guineapig complement, and overnight fixation. Specific complement-fixing antibody was demonstrable...

SWINE FEVER: a trial of the Chinese strain of lapinized virus showed that it was safe to use as a vaccine in Belgium. Antibodies to porcine picorna-virus (SMEDI virus) were found in at least 59 of 194 serum samples; their incidence did not seem to be related to abortion and sterility. A comparison...

Three attenuated strains were produced by passaging Strain 119 (Type A) in either unweaned or weaned mice, or in chick embryos. After 102 passages in weaned or 78 passages in unweaned mice, steers remained free from clin, disease after inoculation into the tongue epithelium with 10⁶ to 10⁸ ID₅₀ All ...

During 1963, RABIES was confirmed in 47 dogs (from Senegal 10, Ivory Coast 14, Upper Volta 13, Togo 4, Dahomey 3, Mauretania 2, Niger 1), two cats (Upper Volta 1, Niger 1) and a tiger-cat (Togo). Rabies virus was demonstrated in the salivary glands of six of the 14 infected animals examined. In a...

A detailed account is given of: attenuation of the F. & M. disease virus (by passage in white mice, and in 14-day chick embryos); tests for attenuation (in cattle, guineapigs and adult mice); cattle innocuity tests and small animal experiments; storage of attenuated strains and preparation of...

At the Amsterdam Branch of the Central Veterinary Laboratory (director: Dr. J G. van Bekkum) 4 million doses of FOOT AND MOUTH DISEASE vaccine (against types O₁ and O₂) for cattle and 1 million doses for pigs were produced. Research on vaccine production and immunization of pigs continued. Attempts ...

Foot and mouth disease virus. Type A. was rendered avirulent by 28 passages in day old chicks or 12 in embryonated eggs. These strains, were non-pathogenic, had good antigenicity and did not spread by contact. In field trials with the chick embryo strain immunity lasted at least eight months....

This is a summary of the studies made at Insel Riems. The standard Vallée O type g. pig strain has been given more than 300 passages in eggs. Virus appears in the egg fluids 12-18 hours after inoculation of the chorio-allantoic membrane, and during the next six hours in the embryos from which the...

An outbreak of disease among guineapigs was due to Pasteurella pseudotuberculosis, and was eradicated by the use of a slide agglutination test.
OVINE BRUCELLOSIS can be transmitted to clean rams grazing with infected rams, but not by grazing pastures previously grazed by the infected animals. The...