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Abstract

It has been suggested that Sarcocystis species are associated with bovine eosinophilic myositis (BEM). To date, parasite identification in this myopathy has been based on morphological techniques. The aim of the present study was to use molecular techniques to identify Sarcocystis species inside...

Author(s)
Vangeel, L.; Houf, K.; Geldhof, P.; Preter, K. de; Vercruysse, J.; Ducatelle, R.; Chiers, K.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2013, 197, 3/4, pp 543-548
Abstract

Activation associated secreted proteins (ASP) are members of a nematode-specific protein family belonging to the SCP/Tpx-1/Ag5/PR-1/Sc7 family. Three different types of molecules have been identified in this family: two-domain ASPs and single-domain ASPs showing homology to either the C-terminal or ...

Author(s)
Visser, A.; Zeveren, A. M. van; Meyvis, Y.; Peelaers, I.; Broeck, W. van den; Gevaert, K.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
International Journal for Parasitology, 2008, 38, 3/4, pp 455-465
Abstract

Giardia duodenalis causes diarrhoea in humans and a wide range of mammals, including cattle. In cattle, the infection often has a chronic character. Infected calves may excrete cysts for several months, suggesting that Giardia is able to suppress and evade the immune response. In this study six...

Author(s)
Grit, G. H.; Coppernolle, S. van; Devriendt, B.; Geurden, T.; Dreesen, L.; Hope, J.; Vercruysse, J.; Cox, E.; Geldhof, P.; Claerebout, E.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2014, 202, 3/4, pp 145-155
Abstract

Recent reports of suspected ivermectin (IVM) resistance in Ostertagia ostertagi have highlighted the need for research into the mechanisms of IVM resistance. However, there are no reports of resistant field isolates of O. ostertagi, which have been characterized for molecular research. Therefore,...

Author(s)
Zeveren, A. M. van; Casaert, S.; Alvinerie, M.; Geldhof, P.; Claerebout, E.; Vercruysse, J.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2007, 150, 1/2, pp 104-110
Abstract

Previous vaccination trials with calves have shown that intramuscular immunization with natively purified activation-associated secreted proteins (ASPs) of Ostertagia ostertagi induces protection against a homologous challenge infection with a 74% reduction in cumulative faecal egg counts and a...

Author(s)
Meyvis, Y.; Callewaert, N.; Gevaert, K.; Timmerman, E.; Durme, J. van; Schymkowitz, J.; Rousseau, F.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
Molecular and Biochemical Parasitology, 2008, 161, 1, pp 67-71
Abstract

This paper compares 2 methods, the coefficient of variation and the geNorm software programme, for the evaluation of 5 potential reference genes in the cattle parasite Ostertagia ostertagi to be used for quantitative real-time polymerase chain reaction (PCR) analysis. Both methods identified Tubb...

Author(s)
Zeveren, A. M. van; Visser, A.; Hoorens, P. R.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
Molecular and Biochemical Parasitology, 2007, 153, 2, pp 224-227
Abstract

Control of helminth infections is a major task in livestock production to prevent health constraints and economic losses. However, resistance to established anthelmintic substances already impedes effective anthelmintic treatment in many regions worldwide. Thus, there is an obvious need for...

Author(s)
Demeler, J.; Krüger, N.; Krücken, J.; Heyden, V. C. von der; Ramünke, S.; Küttler, U.; Miltsch, S.; López Cepeda, M.; Knox, M.; Vercruysse, J.; Geldhof, P.; Harder, A.; Samson-Himmelstjerna, G. von
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2013, 8, 8, pp e70212
Abstract

The cysteine-rich secretory/antigen 5/pathogenesis-related 1 (CAP) protein superfamily is composed of a functionally diverse group of members that are found in both eukaryotes and prokaryotes. The excretome/secretome of numerous helminths (parasitic nematodes) contains abundant amounts of CAP...

Author(s)
Borloo, J.; Geldhof, P.; Peelaers, I.; Meulder, F. van; Ameloot, P.; Callewaert, N.; Vercruysse, J.; Claerebout, E.; Strelkov, S. V.; Weeks, S. D.
Publisher
Wiley-Blackwell, Copenhagen, Denmark
Citation
Acta Crystallographica Section D, Biological Crystallography, 2013, 69, 4, pp 493-503
Abstract

Infections in cattle with the gastric nematode Ostertagia ostertagi are associated with decreased acid secretion and profound physio-morphological changes of the gastric mucosa. The purpose of the current study was to investigate the mechanisms triggering these pathophysiological changes. O....

Author(s)
Mihi, B.; Meulder, F. van; Rinaldi, M.; Coppernolle, S. van; Chiers, K.; Broeck, W. van den; Goddeeris, B.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
BioMed Central Ltd, London, UK
Citation
Veterinary Research, 2013, 44, 121, pp (11 December 2013)
Abstract

Ostertagia ostertagi is considered one of the most economically important bovine parasites. As an alternative to anthelmintic treatment, an experimental host-protective vaccine was previously developed on the basis of ASP proteins derived from adult worms. Intramuscular injection of this vaccine,...

Author(s)
Meulder, F. van; Coppernolle, S. van; Borloo, J.; Rinaldi, M.; Li, R. W.; Chiers, K.; Broeck, W. van den; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Infection and Immunity, 2013, 81, 5, pp 1798-1809

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