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Abstract

One of five Tunisian isolates of Theileria annulata was polymorphic and virulent, while the other 4 were less virulent. 200 passages in culture resulted in subpopulation selection in two cases. Vaccine prepared from a less virulent isolate passaged 100 times failed to provide adequate protection. ...

Author(s)
Dargouth, M. E. A.; Bouattour, A.; Miled, L. B.; Kilani, M.; Brown, C. G. D.
Publisher
CIRAD, Maisons-Alfort, France
Citation
Resistance or tolerance of animals to disease and veterinary epidemiology and diagnostic methods., 1993, pp 162
Abstract

A pilot series of experiments was conducted in which cattle, sheep and goats were infected with sporozoites of a single stock of each of Theileria annulata and T. lestoquardi (syn T. hirci) from a laboratory colony of Hyalomma anatolicum anatolicum. Reciprocal cross-immunity and serological studies ...

Author(s)
Brown, C. G. D.; Ilhan, T.; Kirvar, E.; Thomas, M.; Wilkie, G.; Leemans, I.; Hooshmand-Rad, P.
Citation
Annals of the New York Academy of Sciences, 1998, 849, pp 44-51
Abstract

Cattle were immunized with SPAG-1 (a sporozoite surface antigen of Theileria annulata), as a fusion protein with a His6 tag, either incorporated into ISCOMs (immunostimulatory complexes), with or without the merozoite antigens TAMS 1-1 and 1-2, or with RWL (a proprietary saponin-based adjuvant) as...

Author(s)
Boulter, N. R.; Brown, C. G. D.; Kirvar, E.; Glass, E.; Campbell, J.; Morzaria, S.; Nene, V.; Musoke, A.; D'Oliveira, C.; Gubbels, M. J.; Jongejan, F.; Hall, F. R.
Citation
Annals of the New York Academy of Sciences, 1998, 849, pp 234-246
Abstract

Author(s)
Leemans, I.; Hooshmand-Rad, P.; Brown, C. G. D.; Kirvar, E.; Wilkie, G.; Uggla, A.
Citation
Annals of the New York Academy of Sciences, 1998, 849, pp 408-411
Abstract

A series of studies on Theileria annulata have provided convincing evidence that macrophage and natural killer cell-dependent immune mechanisms may directly control the proliferation of different stages of T. annulata in cattle. The evidence for this conclusion and the implications for vaccine...

Author(s)
Preston, P. M.; Visser, A.; Abraham, A.; Richardson, W.; Richardson, J.; Forsyth, L.; Bell-Sakyi, L.; Wilkie, G.; Entrican, G.; Boid, R.; Spooner, R. L.; Brown, C. G. D.
Citation
Tropical Animal Health and Production, 1997, 29, 4 (supplement), pp 136S-138S
Abstract

Calves were infected with Theileria annulata sporozoites, low passage (non-attenuated) or high passage (attenuated, vaccine) cell lines and later challenged with a lethal dose of heterologous sporozoites. The presence and persistence of the parasite were monitored by PCR using primers derived from...

Author(s)
Ilhan, T.; Williamson, S.; Kirvar, E.; Shiels, B.; Brown, C. G. D.
Citation
Annals of the New York Academy of Sciences, 1998, 849, pp 109-125
Abstract

The objective of this study was to determine whether Bos taurus cattle differ form Bos indicus in their susceptibility to infection with the Muguga stabilate of Theileria parva and in their resistance to the resultant disease. Ten Friesians (B. taurus), ten improved Borans (B. indicus), ten...

Author(s)
Ndungu, S. G.; Brown, C. G. D.; Dolan, T. T.
Publisher
Onderstepoort Veterinary Institute, Onderstepoort, South Africa
Citation
Onderstepoort Journal of Veterinary Research, 2005, 72, 1, pp 13-22
Abstract

Disease-resistant livestock could provide a potentially sustainable and environmentally sound method of controlling tick and tick-borne diseases of livestock in the developing world. Advances in the knowledge and science of genomics open up opportunities to identify selectable genes controlling...

Author(s)
Glass, E. J.; Preston, P. M.; Springbett, A.; Craigmile, S.; Kirvar, E.; Wilkie, G.; Brown, C. G. D.
Publisher
Elsevier, Oxford, UK
Citation
International Journal for Parasitology, 2005, 35, 3, pp 337-347
Abstract

Acute phase proteins (APP) are synthesised in the liver in response to the systemic presence of high levels of pro-inflammatory cytokines. Bacteria are considered to be strong inducers of APP whereas viruses are weak or non-inducers of APP. Very few reports have been published on APP induction by...

Author(s)
Glass, E. J.; Craigmile, S. C.; Springbett, A.; Preston, P. M.; Kirvar, E.; Wilkie, G. M.; Eckersall, P. D.; Hall, F. R.; Brown, C. G. D.
Publisher
Elsevier Science Ltd, Oxford, UK
Citation
International Journal for Parasitology, 2003, 33, 12, pp 1409-1418
Abstract

This review of the application of in vitro techniques to the vaccination of cattle against theileriosis includes notes on the use of ticks to transmit species of Theileria in the laboratory, and the use of tick-derived stabilates to inoculate cattle.

Author(s)
Brown, C. G. D.
Publisher
Martinus Nijhoff Publishers, The Hague, Netherlands
Citation
Advances in the Control of Theileriosis. Proceedings of an International Conference held at the International Laboratory for Research on Animal Diseases in Nairobi, 9-13th February, 1981, 1981, pp 104-119

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