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Abstract

Anthelmintic resistance of parasites in small ruminants, cattle and horses is increasing worldwide as a consequence of the over usage of the currently available products. In Belgium, Cooperia oncophora is the most common cattle nematode in which resistance, especially against macrocyclic lactones,...

Author(s)
Graef, J. de; Claerebout, E.; Geldhof, P.
Publisher
Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium
Citation
Vlaams Diergeneeskundig Tijdschrift, 2013, 82, 3, pp 113-123
Abstract

The mucus-dwelling parasite Ostertagia ostertagi is one of the most important gastrointestinal nematodes in cattle. Our group has previously demonstrated the protective capacity of a vaccine against this parasite based on a native activation-associated secreted protein ASP1 (nASP) in combination...

Author(s)
González-Hernández, A.; Coppernolle, S. van; Borloo, J.; Meulder, F. van; Paerewijck, O.; Peelaers, I.; Leclercq, G.; Claerebout, E.; Geldhof, P.
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2016, 6, 1, pp 29496
Abstract

Gastrointestinal nematodes (GIN) of ruminants (cattle, sheep and goats) are ubiquitous and can cause severe injuries to infected animals and significant losses in farming revenues. GIN are able to survive severe environmental and host conditions, but mankind has developed a number of ingenious...

Author(s)
Molento, M. B.; Fortes, F. S.; Pondelek, D. A. S.; Borges, F. de A.; Chagas, A. C. de S.; Torres-Acosta, J. F. de J.; Geldhof, P.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Parasitology, 2011, 180, 1/2, pp 126-132
Abstract

Resistance against macrocyclic lactones such as ivermectin is widespread among parasitic gastrointestinal nematodes of small ruminants and is rapidly increasing in cattle parasites. ABC transporters of the subfamily B, the so-called P-glycoproteins (Pgps) have been frequently implicated in...

Author(s)
Demeler, J.; Krücken, J.; AlGusbi, S.; Ramünke, S.; Graef, J. de; Kerboeuf, D.; Geldhof, P.; Pomroy, W. E.; Samson-Himmelstjerna, G. von
Publisher
Elsevier Ltd, Oxford, UK
Citation
Molecular and Biochemical Parasitology, 2013, 188, 1, pp 10-19
Abstract

The global increase in anthelmintic resistant nematodes of ruminants, together with consumer concerns about chemicals in food, necessitates the development of alternative methods of control for these pathogens. Subunit recombinant vaccines are ideally placed to fill this gap. Indeed, they are...

Author(s)
Matthews, J. B.; Geldhof, P.; Tzelos, T.; Claerebout, E.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Parasite Immunology, 2016, 38, 12, pp 744-753
Abstract

Control of helminth infections is a major task in livestock production to prevent health constraints and economic losses. However, resistance to established anthelmintic substances already impedes effective anthelmintic treatment in many regions worldwide. Thus, there is an obvious need for...

Author(s)
Demeler, J.; Krüger, N.; Krücken, J.; Heyden, V. C. von der; Ramünke, S.; Küttler, U.; Miltsch, S.; López Cepeda, M.; Knox, M.; Vercruysse, J.; Geldhof, P.; Harder, A.; Samson-Himmelstjerna, G. von
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2013, 8, 8, pp e70212
Abstract

Activation associated secreted proteins (ASP) are members of a nematode-specific protein family belonging to the SCP/Tpx-1/Ag5/PR-1/Sc7 family. Three different types of molecules have been identified in this family: two-domain ASPs and single-domain ASPs showing homology to either the C-terminal or ...

Author(s)
Visser, A.; Zeveren, A. M. van; Meyvis, Y.; Peelaers, I.; Broeck, W. van den; Gevaert, K.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
International Journal for Parasitology, 2008, 38, 3/4, pp 455-465
Abstract

Background: Cooperia oncophora and Ostertagia ostertagi are among the most important gastrointestinal nematodes of cattle worldwide. The economic losses caused by these parasites are on the order of hundreds of millions of dollars per year. Conventional treatment of these parasites is through...

Author(s)
Heizer, E.; Zarlenga, D. S.; Rosa, B.; Gao, X.; Gasser, R. B.; Graef, J. de; Geldhof, P.; Mitreva, M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2013, 14, 118, pp (22 February 2013)
Abstract

The cysteine-rich secretory/antigen 5/pathogenesis-related 1 (CAP) protein superfamily is composed of a functionally diverse group of members that are found in both eukaryotes and prokaryotes. The excretome/secretome of numerous helminths (parasitic nematodes) contains abundant amounts of CAP...

Author(s)
Borloo, J.; Geldhof, P.; Peelaers, I.; Meulder, F. van; Ameloot, P.; Callewaert, N.; Vercruysse, J.; Claerebout, E.; Strelkov, S. V.; Weeks, S. D.
Publisher
Wiley-Blackwell, Copenhagen, Denmark
Citation
Acta Crystallographica Section D, Biological Crystallography, 2013, 69, 4, pp 493-503
Abstract

Infections in cattle with the gastric nematode Ostertagia ostertagi are associated with decreased acid secretion and profound physio-morphological changes of the gastric mucosa. The purpose of the current study was to investigate the mechanisms triggering these pathophysiological changes. O....

Author(s)
Mihi, B.; Meulder, F. van; Rinaldi, M.; Coppernolle, S. van; Chiers, K.; Broeck, W. van den; Goddeeris, B.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
BioMed Central Ltd, London, UK
Citation
Veterinary Research, 2013, 44, 121, pp (11 December 2013)

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