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Abstract

An overview of the chemotherapy research programme against trypanosomiasis undertaken at the International Laboratory for Research on Animal Diseases in Kenya, is given. Work carried out is grouped under the following 8 broad topics: development of in vitro culture techniques for identifying and...

Author(s)
Peregrine, A. S.; Sutherland, I. A.; Mutharia, L.; Jamnadass, R.; Gray, M. A.; Codjia, V.; Aliu, Y. O.; Mamman, M.; Silayo, R.; D'Ieteren, G. D. M.; Moloo, S. K.; Murphy, N. B.
Publisher
International Laboratory for Research on Animal Diseases, Nairobi, Kenya
Citation
Chemotherapy for trypanosomiasis. Proceedings of a workshop held at ILRAD, Nairobi, Kenya, 21-24 August, 1989., 1990, pp 3-8
Abstract

To determine the duration after treatment of cattle with diminazene aceturate (Berenil) that the drug influences the tsetse infectivity and transmissibility of a drug-resistant T. congolense, 6 Boran zebu cattle were infected with T. congolense IL 3338 via the bites of G. morsitans centralis. At...

Author(s)
Diack, A.; Moloo, S. K.; Peregrine, A. S.
Citation
Veterinary Parasitology, 1997, 70, 1/3, pp 13-23
Abstract

5 cattle were treated intramuscularly with isometamidium chloride at a dose rate of 0.5mg/kg body weight (bw) and challenged 28 days later with 5 Glossina morsitans centralis infected with T. congolense IL 3580 (a clone which exhibits a low level of resistance to isometamidium chloride). All 5 ...

Author(s)
Sutherland, I. A.; Codjia, V.; Moloo, S. K.; Holmes, P. H.; Peregrine, A. S.
Citation
Tropical Animal Health and Production, 1992, 24, 3, pp 157-163
Abstract

Author(s)
Sutherland, I. A.; Moloo, S. K.; Holmes, P. H.; Peregrine, A. S.
Citation
Publication - International Scientific Council for Trypanosomiasis Research and Control, 1991, No.115, pp 514-515
Abstract

An investigation was conducted on the therapeutic and prophylactic activity of isometamidium chloride (Samorin) in Boran cattle (Bos indicus) against a T. congolense clone, IL 3270. This clone was derived, without drug selection, from a stock originally isolated in Burkina Faso and has previously...

Author(s)
Sutherland, I. A.; Moloo, S. K.; Holmes, P. H.; Peregrine, A. S.
Citation
Acta Tropica, 1991, 49, 1, pp 57-64
Abstract

Ten Boran steers were infected with T. vivax, transmitted by G. morsitans centralis; five steers with a T. vivax clone from Nigeria and five with a T. vivax clone from Kenya. Eleven days after infection all 10 animals were treated with 0.5 mg/kg isometamidium chloride. Four steers infected with the ...

Author(s)
Peregrine, A. S.; Moloo, S. K.; Whitelaw, D. D.
Citation
Research in Veterinary Science, 1987, 43, 2, pp 268-270
Abstract

Isometamidium chloride was administered as a single prophylactic dose of 0.5 mg/kg bwt to each of 10 Boran (Bos indicus) steers. At monthly intervals following drug administration, groups of 5 cattle each were challenged with one of 2 different T. vivax populations (stock IL 2982 from Galana, Kenya ...

Author(s)
Peregrine, A. S.; Moloo, S. K.; Whitelaw, D. D.
Citation
Tropical Animal Health and Production, 1991, 23, 1, pp 29-38
Abstract

The drug sensitivity of 7 T. vivax isolates from Kenya and Somalia was examined. With the exception of diminazene aceturate all commercially available trypanocidal drugs failed to effect a cure. The results suggest the existence of multiple drug resistance of T. vivax strains, geographically widely ...

Author(s)
Schönefeld, A.; Röttcher, D.; Moloo, S. K.
Citation
Tropical Medicine and Parasitology, 1987, 38, 3, pp 177-180
Abstract

A 9-month study of the epidemiology of animal trypanosomiasis was carried out on a 2500-ha cattle ranch, with a history of trypanosomiasis, in the Coast Province of Kenya in 1982. One breeding focus of Glossina austeni was discovered in a thicket of approximately 50 ha. Trypanosomes were detected...

Author(s)
Paling, R. W.; Leak, S. G. A.; Katende, J.; Kamunya, G.; Moloo, S. K.
Citation
Acta Tropica, 1987, 44, 1, pp 67-82

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