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Abstract

Background: In the mammary gland transcriptome of lactating dairy cows genes encoding milk proteins are highly abundant, which can impair the detection of lowly expressed transcripts and can bias the outcome in global transcriptome analyses. Therefore, the aim of this study was to develop and...

Author(s)
Brodhagen, J.; Weikard, R.; Thom, U.; Heimes, A.; Günther, J.; Hadlich, F.; Zerbe, H.; Petzl, W.; Meyerholz, M. M.; Hoedemaker, M.; Schuberth, H. J.; Engelmann, S.; Kühn, C.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2019, 20, 400, pp (22 May 2019)
Abstract

Bovine mastitis is a disease of major economic effects on the dairy industry worldwide. Experimental in vivo infection models have been widely proven as an effective tool for the investigation of pathogen-specific host immune responses. Staphylococcus aureus (S. aureus) and Escherichia coli (E....

Author(s)
Petzl, W.; Zerbe, H.; Günther, J.; Seyfert, H. M.; Jamal Hussen; Schuberth, H. J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2018, 116, pp 55-61
Abstract

The etiology determines quality and extent of the immune response after udder infection (mastitis). Infections with Gram negative bacteria (e.g. Escherichia coli) will quickly elicit strong inflammation of the udder, fully activate its immune defence via pathogen receptor driven activation of...

Author(s)
Günther, J.; Petzl, W.; Bauer, I.; Ponsuksili, S.; Zerbe, H.; Schuberth, H. J.; Brunner, R. M.; Seyfert, H. M.
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2017, 7, 1, pp 4811
Abstract

The outcome of an udder infection (mastitis) largely depends on the species of the invading pathogen. Gram-negative pathogens, such as Escherichia coli often elicit acute clinical mastitis while Gram-positive pathogens, such as Staphylococcus aureus tend to cause milder subclinical inflammations....

Author(s)
Günther, J.; Koy, M.; Berthold, A.; Schuberth, H. J.; Seyfert, H. M.
Publisher
BioMed Central Ltd, London, UK
Citation
Veterinary Research, 2016, 47, 22, pp (1 February 2016)
Abstract

We examined the repertoire and extent of inflammation dependent gene regulation in a bovine mammary epithelial cell (MEC) model, to better understand the contribution of the MEC in the immune defence of the udder. We challenged primary cultures of MEC from cows with heat inactivated Escherichia...

Author(s)
Günther, J.; Koczan, D.; Yang Wei; Nürnberg, G.; Repsilber, D.; Schuberth, H. J.; Park, Z.; Maqbool, N.; Molenaar, A.; Seyfert, H. M.
Publisher
EDP Sciences, Les Ulis, France
Citation
Veterinary Research, 2009, 40, 4, pp 40:31
Abstract

Many different bacterial species have the ability to cause an infection of the bovine mammary gland and the host response to these infections is what we recognize as mastitis. In this review we evaluate the pathogen specific response to the three main bacterial species causing bovine mastitis: ...

Author(s)
Schukken, Y. H.; Günther, J.; Fitzpatrick, J.; Fontaine, M. C.; Goetze, L.; Holst, O.; Leigh, J.; Petzl, W.; Schuberth, H. J.; Sipka, A.; Smith, D. G. E.; Quesnell, R.; Watts, J.; Yancey, R.; Zerbe, H.; Gurjar, A.; Zadoks, R. N.; Seyfert, H. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Immunology and Immunopathology, 2011, 144, 3/4, pp 270-289
Abstract

As one of the most potent and hazardous feed/food-originated mycotoxins, aflatoxin (AF) B1 is regarded as a potent immunosuppressor in dairy cows. Neutrophils (PMN), as key effector cells against pathogens, have a high potential to kill engulfed microbes. To investigate the in vitro effects of very ...

Author(s)
Mehrzad, J.; Klein, G.; Kamphues, J.; Wolf, P.; Grabowski, N.; Schuberth, H. J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Immunology and Immunopathology, 2011, 141, 1/2, pp 16-25

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