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Abstract

Nematode infections modulate the immune reaction of humans and livestock and may impair immune responses to non-parasitic antigens such as those present in vaccines. In this study, the relationship between antibodies directed against Ostertagia ostertagi, the economically most important nematode...

Author(s)
Charlier, J.; Forbes, A.; Gucht, S. van; Duchateau, L.; Goddeeris, B. M.; Vercruysse, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2013, 95, 3, pp 1055-1058
Abstract

Ostertagia ostertagi is considered one of the most economically important bovine parasites. As an alternative to anthelmintic treatment, an experimental host-protective vaccine was previously developed on the basis of ASP proteins derived from adult worms. Intramuscular injection of this vaccine,...

Author(s)
Meulder, F. van; Coppernolle, S. van; Borloo, J.; Rinaldi, M.; Li, R. W.; Chiers, K.; Broeck, W. van den; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Infection and Immunity, 2013, 81, 5, pp 1798-1809
Abstract

Previous vaccination trials with calves have shown that intramuscular immunization with natively purified activation-associated secreted proteins (ASPs) of Ostertagia ostertagi induces protection against a homologous challenge infection with a 74% reduction in cumulative faecal egg counts and a...

Author(s)
Meyvis, Y.; Callewaert, N.; Gevaert, K.; Timmerman, E.; Durme, J. van; Schymkowitz, J.; Rousseau, F.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
Molecular and Biochemical Parasitology, 2008, 161, 1, pp 67-71
Abstract

Intramuscular immunization of calves with an excretory-secretory antigen fraction enriched for cysteine proteinase activity (ES-thiol) and QuilA as adjuvant induces a protective immune response against the abomasal nematode Ostertagia ostertagi. A study was conducted to confirm the protective...

Author(s)
Geldhof, P.; Vercauteren, I.; Vercruysse, J.; Knox, D. P.; Broeck, W. van den; Claerebout, E.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Parasite Immunology, 2004, 26, 1, pp 37-43
Abstract

This review discusses the immune responses to gastrointestinal nematodes in cattle and the different immunological and parasitological parameters used to assess acquired immunity. Measuring acquired immunity to gastrointestinal nematodes in cattle (e.g. for the evaluation of candidate parasite...

Author(s)
Claerebout, E.; Vercruysse, J.
Citation
Parasitology, 2000, 120, supplement, pp S25-S42
Abstract

The contribution of different bovine cell subpopulations in the development of in vitro induced responses by O. ostertagi third larval antigen extract (L3) was investigated in bovine abomasal lymph node cell suspensions depleted of specific cell populations. The depleted cell suspensions were...

Author(s)
Marez, T. de; Cox, E.; Vercruysse, J.; Goddeeris, B. M.
Citation
Veterinary Immunology and Immunopathology, 2000, 73, 2, pp 145-154
Abstract

Previous vaccination trials against the economically important cattle parasite Ostertagia ostertagi have indicated the protective capacity of activation-associated secreted proteins (ASPs). The further development of these antigens into a commercial vaccine will require their recombinant...

Author(s)
Geldhof, P.; Meyvis, Y.; Vercruysse, J.; Claerebout, E.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Parasite Immunology, 2008, 30, 1, pp 57-60
Abstract

The protective capacity of an adult stage Ostertagia ostertagi globin antigen was tested in four vaccination experiments in cattle. In a preliminary experiment, calves were vaccinated three times intraperitoneally with 250 µg globin in Freund's adjuvant and challenged with a trickled infection of...

Author(s)
Claerebout, E.; Smith, W. D.; Pettit, D.; Geldhof, P.; Raes, S.; Geurden, T.; Vercruysse, J.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2005, 128, 3/4, pp 299-307
Abstract

The responses of peripheral blood and lymph node lymphocytes to O. ostertagi antigen extracts were determined in O. ostertagi-exposed and naive calves. The lymphocyte responses induced by O. ostertagi antigen extracts of the third (L3) and fourth (L4) larval stages, as well as adult worms, were...

Author(s)
Marez, T. de; Cox, E.; Claerebout, E.; Vercruysse, J.; Goddeeris, B. M.
Citation
Veterinary Immunology and Immunopathology, 1997, 57, 1/2, pp 69-77
Abstract

Antigenic differences between the developmental stages of O. ostertagi were studied by SDS-PAGE and Western blotting. Gel electrophoresis showed a complex protein pattern different for every stage with the O. ostertagi fourth stage larvae (L4) showing an intermediate protein pattern between the...

Author(s)
Hilderson, H.; Graaf, D. C. de; Vercruysse, J.; Berghen, P.
Citation
Research in Veterinary Science, 1993, 55, 2, pp 203-208

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