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Abstract

Previous vaccination trials with calves have shown that intramuscular immunization with natively purified activation-associated secreted proteins (ASPs) of Ostertagia ostertagi induces protection against a homologous challenge infection with a 74% reduction in cumulative faecal egg counts and a...

Author(s)
Meyvis, Y.; Callewaert, N.; Gevaert, K.; Timmerman, E.; Durme, J. van; Schymkowitz, J.; Rousseau, F.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
Molecular and Biochemical Parasitology, 2008, 161, 1, pp 67-71
Abstract

Giardia duodenalis causes diarrhoea in humans and a wide range of mammals, including cattle. In cattle, the infection often has a chronic character. Infected calves may excrete cysts for several months, suggesting that Giardia is able to suppress and evade the immune response. In this study six...

Author(s)
Grit, G. H.; Coppernolle, S. van; Devriendt, B.; Geurden, T.; Dreesen, L.; Hope, J.; Vercruysse, J.; Cox, E.; Geldhof, P.; Claerebout, E.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2014, 202, 3/4, pp 145-155
Abstract

Ostertagia ostertagi is considered one of the most economically important bovine parasites. As an alternative to anthelmintic treatment, an experimental host-protective vaccine was previously developed on the basis of ASP proteins derived from adult worms. Intramuscular injection of this vaccine,...

Author(s)
Meulder, F. van; Coppernolle, S. van; Borloo, J.; Rinaldi, M.; Li, R. W.; Chiers, K.; Broeck, W. van den; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Infection and Immunity, 2013, 81, 5, pp 1798-1809
Abstract

Giardia duodenalis is an important intestinal parasite in animals and humans. The role of dendritic cells (DC) in the initiation of the immune response against G. duodenalis is poorly documented. The aim of this study was to test the hypothesis that G. duodenalis interferes with bovine DC function. ...

Author(s)
Grit, G. H.; Devriendt, B.; Coppernolle, S. van; Geurden, T.; Hope, J.; Vercruysse, J.; Cox, E.; Geldhof, P.; Claerebout, E.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Parasite Immunology, 2014, 36, 4, pp 157-169
Abstract

Intramuscular immunization of calves with an excretory-secretory antigen fraction enriched for cysteine proteinase activity (ES-thiol) and QuilA as adjuvant induces a protective immune response against the abomasal nematode Ostertagia ostertagi. A study was conducted to confirm the protective...

Author(s)
Geldhof, P.; Vercauteren, I.; Vercruysse, J.; Knox, D. P.; Broeck, W. van den; Claerebout, E.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Parasite Immunology, 2004, 26, 1, pp 37-43
Abstract

This review discusses the immune responses to gastrointestinal nematodes in cattle and the different immunological and parasitological parameters used to assess acquired immunity. Measuring acquired immunity to gastrointestinal nematodes in cattle (e.g. for the evaluation of candidate parasite...

Author(s)
Claerebout, E.; Vercruysse, J.
Citation
Parasitology, 2000, 120, supplement, pp S25-S42
Abstract

The responses of peripheral blood and lymph node lymphocytes to O. ostertagi antigen extracts were determined in O. ostertagi-exposed and naive calves. The lymphocyte responses induced by O. ostertagi antigen extracts of the third (L3) and fourth (L4) larval stages, as well as adult worms, were...

Author(s)
Marez, T. de; Cox, E.; Claerebout, E.; Vercruysse, J.; Goddeeris, B. M.
Citation
Veterinary Immunology and Immunopathology, 1997, 57, 1/2, pp 69-77
Abstract

The evolution of antigenically distinct pathogen strains that fail to cross-protect is well documented for pathogens controlled primarily by humoral immune responses. Unlike antibodies, which recognise native proteins, protective T cells can potentially recognise epitopes in a variety of proteins...

Author(s)
Morrison, W. I.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2007, 148, 1, pp 21-30
Abstract

The objective of this study was to conduct a comprehensive field survey using a Dictyocaulus viviparus major sperm protein ELISA on bulk tank milk samples from Belgian dairy herds to gain insights in: (1) the sensitivity (Se) and specificity (Sp) of the test under field conditions; (2) the value of ...

Author(s)
Charlier, J.; Ghebretinsae, A.; Meyns, T.; Czaplicki, G.; Vercruysse, J.; Claerebout, E.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2016, 232, pp 36-42
Abstract

The protective capacity of an adult stage Ostertagia ostertagi globin antigen was tested in four vaccination experiments in cattle. In a preliminary experiment, calves were vaccinated three times intraperitoneally with 250 µg globin in Freund's adjuvant and challenged with a trickled infection of...

Author(s)
Claerebout, E.; Smith, W. D.; Pettit, D.; Geldhof, P.; Raes, S.; Geurden, T.; Vercruysse, J.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2005, 128, 3/4, pp 299-307

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