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Abstract

The mucus-dwelling parasite Ostertagia ostertagi is one of the most important gastrointestinal nematodes in cattle. Our group has previously demonstrated the protective capacity of a vaccine against this parasite based on a native activation-associated secreted protein ASP1 (nASP) in combination...

Author(s)
González-Hernández, A.; Coppernolle, S. van; Borloo, J.; Meulder, F. van; Paerewijck, O.; Peelaers, I.; Leclercq, G.; Claerebout, E.; Geldhof, P.
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2016, 6, 1, pp 29496
Abstract

The global increase in anthelmintic resistant nematodes of ruminants, together with consumer concerns about chemicals in food, necessitates the development of alternative methods of control for these pathogens. Subunit recombinant vaccines are ideally placed to fill this gap. Indeed, they are...

Author(s)
Matthews, J. B.; Geldhof, P.; Tzelos, T.; Claerebout, E.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Parasite Immunology, 2016, 38, 12, pp 744-753
Abstract

Recently we reported the successful vaccination of calves against Cooperia oncophora with a double domain activation-associated secreted protein, purified from the excretory-secretory material of adult stage parasites. In an attempt to elucidate the immune mechanisms involved in protection, the...

Author(s)
Meulder, F. van; Ratman, D.; Coppernolle, S. van; Borloo, J.; Li, R. W.; Chiers, K.; Broeck, W. van den; Bosscher, K. de; Claerebout, E.; Geldhof, P.
Publisher
Elsevier Ltd, Oxford, UK
Citation
International Journal for Parasitology, 2015, 45, 9/10, pp 637-646
Abstract

The protective capacities of a native double-domain activation-associated secreted protein (ndd-ASP)-based vaccine against the cattle intestinal nematode Cooperia oncophora has previously been demonstrated. However, protection analysis upon vaccination with a recombinantly produced antigen has...

Author(s)
Gonźlez-Herńndez, A.; Borloo, J.; Peelaers, I.; Casaert, S.; Leclercq, G.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier Ltd, Oxford, UK
Citation
International Journal for Parasitology, 2018, 48, 1, pp 41-49
Abstract

Ostertagia ostertagi is considered one of the most economically important bovine parasites. As an alternative to anthelmintic treatment, an experimental host-protective vaccine was previously developed on the basis of ASP proteins derived from adult worms. Intramuscular injection of this vaccine,...

Author(s)
Meulder, F. van; Coppernolle, S. van; Borloo, J.; Rinaldi, M.; Li, R. W.; Chiers, K.; Broeck, W. van den; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Infection and Immunity, 2013, 81, 5, pp 1798-1809
Abstract

Ostertagia ostertagi is one of the most important gastrointestinal parasites infecting millions of cattle in temperate climate areas. Because infection leads to significant losses in productivity, farmers are pushed, because of the on-going intensification of the livestock production systems, to...

Author(s)
Rinaldi, M.; Geldhof, P.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Parasite Immunology, 2012, 34, 5, pp 254-264
Abstract

With the increasing incidence of anthelmintic resistance worldwide, immunological control of worm infections through vaccination is often put forward as a rational and cost-effective alternative for anthelmintic drugs. In this study we report on the evaluation of a double-domain...

Author(s)
Vlaminck, J.; Borloo, J.; Vercruysse, J.; Geldhof, P.; Claerebout, E.
Publisher
Elsevier Ltd, Oxford, UK
Citation
International Journal for Parasitology, 2015, 45, 4, pp 209-213
Abstract

As an alternative to antihelminthic drugs, we are exploiting vaccination to control infections with the abomasal nematode Ostertagia ostertagi in cattle. Our focus for vaccine targets is excretory-secretory (ES) products of this parasite. One of the most abundant antigens in larval and adult ...

Author(s)
Vercauteren, I.; Geldhof, P.; Vercruysse, J.; Peelaers, I.; Broeck, W. van den; Gevaert, K.; Claerebout, E.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Infection and Immunity, 2004, 72, 5, pp 2995-3001
Abstract

Previous vaccination trials against Ostertagia ostertagi in cattle have demonstrated the protective capacity of a protein fraction termed ES-thiol, which is enriched for activation-associated secreted proteins (ASPs) and cysteine proteases. In this study, ES-thiol was subfractionated through...

Author(s)
Meyvis, Y.; Geldhof, P.; Gevaert, K.; Timmerman, E.; Vercruysse, J.; Claerebout, E.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2007, 149, 3/4, pp 239-245
Abstract

The protective capacity of an adult stage Ostertagia ostertagi globin antigen was tested in four vaccination experiments in cattle. In a preliminary experiment, calves were vaccinated three times intraperitoneally with 250 µg globin in Freund's adjuvant and challenged with a trickled infection of...

Author(s)
Claerebout, E.; Smith, W. D.; Pettit, D.; Geldhof, P.; Raes, S.; Geurden, T.; Vercruysse, J.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2005, 128, 3/4, pp 299-307

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