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Abstract

Copy number variation is a large genome variation which usually happens in the noncoding-region, and it may occur at the locus associated with the functional gene to further influence the phenotype. Potassium inwardly-rectifying channel, subfamily J 12 (KCNJ12) gene expressed widely in...

Author(s)
Zheng Li; Xu JiaWei; Li JiChao; Wang DaHui; An QingMing; Xu LinNa; Ma YiLei; Wang Jian; Peng ShuJun; Lei ChuZhao; Lan XianYong; Chen Hong; Huo LiJun; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2019, 689, pp 90-96
Abstract

Copy number variations (CNVs) have been recently recognized as another important genetic variability complementary to single nucleotide polymorphisms (SNPs). Compelling evidence has indicated that CNVs are responsible for phenotypic traits by changing the copy numbers of functional genes. Myosin...

Author(s)
Xu Yao; Shi Tao; Cai HanFang; Zhou Yang; Lan XianYong; Zhang ChunLei; Lei ChuZhao; Qi XingLei; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2014, 535, 2, pp 106-111
Abstract

Copy number variations (CNVs) recently have been recognized as another important genetic variability followed single nucleotide polymorphisms (SNPs). The guanylate binding protein 2 (GBP2) gene plays an important role in cell proliferation. This study was performed to determine the presence of GBP2 ...

Author(s)
Zhang GuiMin; Zheng Li; He Hua; Song ChengChuang; Zhang ZiJing; Cao XiuKai; Lei ChuZhao; Lan XianYong; Qi XingLei; Chen Hong; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2018, 647, pp 101-106
Abstract

Whole-genome sequencing provides a powerful tool to obtain more genetic variability that could produce a range of benefits for cattle breeding industry. Nanyang (Bos indicus) and Qinchuan (Bos taurus) are two important Chinese indigenous cattle breeds with distinct phenotypes. To identify the...

Author(s)
Xu Yao; Jiang Yu; Shi Tao; Cai HanFang; Lan XianYong; Zhao Xin; Plath, M.; Chen Hong
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 8, pp e0183921
Abstract

Neuropeptide Y (NPY) is one of the most potent orexigenic factors that is implicated in the control of feeding behavior and energy homeostasis. Four Chinese indigenous cattle breeds (n=338) were used to detect single nucleotide polymorphisms (SNPs) in the coding regions with their intron-exon...

Author(s)
Zhang Li; Zhang AiLing; Zhang LiangZhi; Zhang Qin; Zhang ChunLei; Lan XianYong; Chen Hong
Publisher
Elsevier, Amsterdam, Netherlands
Citation
General and Comparative Endocrinology, 2011, 170, 1, pp 189-192
Abstract

PCR-SSCP and DNA sequencing methods were employed to screen the genetic variation of vascular endothelial growth factor (VEGF) gene in 675 individuals belonging to three Chinese indigenous cattle breeds including Qinchuan (QC), Jiaxian Red (JX) and Nanyang (NY) breed. Three new single nucleotide...

Author(s)
Pang YongHong; Lei ChuZhao; Zhang ChunLei; Lan XianYong; Yue WangPing; Gu ChuanWen; Chen DanXia; Wang JuQiang; Chen Hong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2011, 38, 5, pp 3219-3225
Abstract

PCR-SSCP and DNA sequencing methods were employed to screen the genetic variation of VEGF gene in 671 individuals belonging to three Chinese indigenous cattle breeds including Nanyang, Jiaxian Red and Qinchuan. Three haplotypes (A, B and C), four observed genotypes (AA, AB, BB and AC) and three new ...

Author(s)
Pang YongHong; Wang JuQiang; Zhang ChunLei; Lei ChuZhao; Lan XianYong; Yue WangPing; Gu ChuanWen; Chen DanXia; Chen Hong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2011, 38, 2, pp 755-759
Abstract

Patatin-like phospholipase domain-containing protein 3 (PNPLA3), a member of the patatin like phospholipase domain-containing (PNPLA) family, plays an important role in energy balance, fat metabolism regulation, glucose metabolism and fatty liver disease. Tetra-primer amplification refractory...

Author(s)
Wang ZiNian; Cai HanFang; Li MingXun; Cao XiuKai; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2016, 575, 2 Part 1, pp 191-198
Abstract

The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, is a metabolic switch, which transcriptionally activates a complex pathway of mitochondrial biogenesis, lipid and glucose metabolism. Three SNPs (exon 3 c.396G>A, intron 9 c.1892+19C>T...

Author(s)
Li MiJie; Liu Mei; Liu Dong; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2014, 41, 1, pp 39-44
Abstract

It is known that the SREBP1c gene is an important gene responsible for adipogenesis and regulation of the expression of genes controlling fatty acid biosynthesis. Its expression levels increase in parallel with obesity. Therefore, the present study focused on screening the genetic variation within...

Author(s)
Huang YongZhen; Zhang EnPing; Wang Jing; Huai YongTao; Lan XianYong; Ma LiAng; Li ZhuanJian; Ren Gang; Chen FuYing; Lei ChuZhao; Wang JuQiang; Chen Hong
Publisher
Taylor & Francis Group, Philadelphia, USA
Citation
Animal Biotechnology, 2010, 21, 3, pp 170-178

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