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Abstract

Copy number variation is a large genome variation which usually happens in the noncoding-region, and it may occur at the locus associated with the functional gene to further influence the phenotype. Potassium inwardly-rectifying channel, subfamily J 12 (KCNJ12) gene expressed widely in...

Author(s)
Zheng Li; Xu JiaWei; Li JiChao; Wang DaHui; An QingMing; Xu LinNa; Ma YiLei; Wang Jian; Peng ShuJun; Lei ChuZhao; Lan XianYong; Chen Hong; Huo LiJun; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2019, 689, pp 90-96
Abstract

NPC1 gene is an important gene closely related to the Niemann-Pick type C (NPC). Mutations in the NPC1 gene tend to cause Niemann-Pick type C, a lysosomal storage disorder. Previous studies have shown that NPC1 protein plays an important role in subcellular lipid transport, homeostasis, platelet...

Author(s)
Dang YongLong; Li MingXun; Yang MingJuan; Cao XiuKai; Lan XianYong; Lei ChuZhao; Zhang ChunLei; Lin Qing; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2014, 540, 2, pp 153-160
Abstract

The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, is a metabolic switch, which transcriptionally activates a complex pathway of mitochondrial biogenesis, lipid and glucose metabolism. Three SNPs (exon 3 c.396G>A, intron 9 c.1892+19C>T...

Author(s)
Li MiJie; Liu Mei; Liu Dong; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2014, 41, 1, pp 39-44
Abstract

Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an interesting novel adipocytokine with insulin-sensitizing effects. Some studies have suggested that vaspin could play an important role in the development of obesity and metabolic disorders. However, the tissue expression...

Author(s)
Lai XinSheng; Zhang ChenGe; Wang Jing; Wang Chen; Lan XianYong; Zhang ChenLei; Lei ChuZhao; Chen Hong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2013, 40, 7, pp 4499-4505
Abstract

Paired box 3 (PAX3) belongs to the PAX superfamily of transcription factors and plays essential roles in the embryogenesis and postnatal formation of limb musculature through affecting the survival of muscle progenitor cells. By genetic mapping, PAX3 gene is assigned in the interval of quantitative ...

Author(s)
Xu Yao; Cai HanFang; Zhou Yang; Shi Tao; Lan XianYong; Zhang ChunLei; Lei ChuZhao; Jia YuTang; Chen Hong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2014, 41, 7, pp 4295-4303
Abstract

Objective: The objective of the present study was to study the genetic effects of polymorphisms of Hinf I, Alu I and Pst I loci within POU1F1 gene exon 6 on Jianxian Red cattle growth traits. Method: POU1F1 gene exon 6 polymorphic fragments were detected by PCR-RFLP technique using 144 Jianxian Red ...

Author(s)
Qiu GuoYu; Chen Hong; Pan ChuanYing; Wang JuQiang; Niu Hui
Publisher
Northwest A & F University (Natural Science Edition), Yangling, China
Citation
Journal of Northwest A & F University - Natural Science Edition, 2009, 37, 5, pp 43-48

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