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Abstract

Copy number variation (CNV) related to complex traits, such as disease and quantitative phenotype, is considered an important and wealthy source of genetic and phenotypic diversity. It suggests that the copy number variation of function gene maybe leads to the phenotypic changes. Kupple like factor ...

Author(s)
Xu JiaWei; Zheng Li; Li LiJuan; Yao YuFei; Hua He; Yang ShiZhen; Wen YiFan; Song ChengChuang; Cao XiuKai; Liu KunPeng; Zhang GuiMin; Yang JiaMeng; Hao Dan; Dang RuiHua; Lan XianYong; Lei ChuZhao; Qi XingLei; Chen Hong; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2019, 680, pp 99-104
Abstract

Copy number variation (CNV) of DNA sequences, functionally significant but yet fully ascertained, is believed to confer considerable increments in unexplained heritability of quantitative traits. Identification of phenotype-associated CNVs (paCNVs) therefore is a pressing need in CNV studies to...

Author(s)
Cao XiuKai; Huang YongZhen; Ma YiLei; Cheng Jie; Qu ZhenXian; Ma Yun; Bai YueYu; Tian Feng; Lin FengPeng; Ma YuLin; Chen Hong
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Functional & Integrative Genomics, 2018, 18, 5, pp 559-567
Abstract

Nanog is an important pluripotent transcription regulator transforming somatic cells to induced pluripotent stem cells (iPSCs), and its overexpression leads to a high expression of the growth and differentiation factor 3 (GDF3), which affects animal growth traits. Therefore, the aim of this study...

Author(s)
Zhang Meng; Pan ChuanYing; Lin Qin; Hu SheNrong; Dang RuiHua; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2016, 59, 3, pp 351-361
Abstract

Copy number variations (CNVs) have been recently recognized as another important genetic variability complementary to single nucleotide polymorphisms (SNPs). Compelling evidence has indicated that CNVs are responsible for phenotypic traits by changing the copy numbers of functional genes. Myosin...

Author(s)
Xu Yao; Shi Tao; Cai HanFang; Zhou Yang; Lan XianYong; Zhang ChunLei; Lei ChuZhao; Qi XingLei; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2014, 535, 2, pp 106-111
Abstract

Background: Copy number variation (CNV) is an important type of genetic variation contributing to phenotypic differences among mammals and may serve as an alternative molecular marker to single nucleotide polymorphism (SNP) for genome-wide association study (GWAS). Recently, GWAS analysis using CNV ...

Author(s)
Zhou Yang; Connor, E. E.; Wiggans, G. R.; Lu YongFang; Tempelman, R. J.; Schroeder, S. G.; Chen Hong; Liu, G. E.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2018, 19, 314, pp (2 May 2018)
Abstract

Copy number variations (CNVs) recently have been recognized as an important source of genetic variability. Compelling evidence has indicated that CNVs are responsible for phenotypic traits by altering the copy numbers of functional genes. The molecule interacting with CasL-like protein 2 (MICAL-L2) ...

Author(s)
Xu Yao; Zhang LiangZhi; Shi Tao; Zhou Yang; Cai HanFang; Lan XianYong; Zhang ChunLei; Lei ChuZhao; Chen Hong
Publisher
Springer, New York, USA
Citation
Mammalian Genome, 2013, 24, 11/12, pp 508-516
Abstract

Muscle growth is a complex phenomenon regulated by many factors, whereby net growth results from the combined action of synthesis and turnover. Insulin-like growth factor 2 (IGF2) is a fetal growth and differentiation factor that plays an important role in muscle growth and in myoblast...

Author(s)
Huang YongZhen; Zhan ZhaoYang; Sun YuJia; Wang Jing; Li MingXun; Lan XianYong; Lei ChuZhao; Zhang ChunLei; Chen Hong
Publisher
NRC Research Press, Ottawa, Canada
Citation
Genome, 2013, 56, 6, pp 327-334
Abstract

Beef production is an economically important sector of animal husbandry and much attention has been paid on the identification of molecular markers associated with gene expressions and growth traits. The aim of this study was to search for potential effects of a novel copy number variation (CNV)...

Author(s)
Liu Mei; Li Bo; Huang YongZhen; Yang MingJuan; Lan XianYong; Lei ChuZhao; Qu WeiDong; Bai YueYu; Chen Hong
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Livestock Science, 2016, 194, pp 44-50
Abstract

Whole-genome sequencing provides a powerful tool to obtain more genetic variability that could produce a range of benefits for cattle breeding industry. Nanyang (Bos indicus) and Qinchuan (Bos taurus) are two important Chinese indigenous cattle breeds with distinct phenotypes. To identify the...

Author(s)
Xu Yao; Jiang Yu; Shi Tao; Cai HanFang; Lan XianYong; Zhao Xin; Plath, M.; Chen Hong
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 8, pp e0183921
Abstract

The F-box protein 32 (FBXO32), also known as Atrogin-1, is one of the four subunits of the ubiquitin protein ligase complex. FBXO32 has been previously shown to be involved in regulation of initiation and development of muscle mass. In the present study, we investigated the polymorphism of FBXO32...

Author(s)
Wang AiLan; Zhang Ya; Li MiJie; Lan XianYong; Wang JuQiang; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2013, 515, 1, pp 181-186

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