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Abstract

Nanog is an important pluripotent transcription regulator transforming somatic cells to induced pluripotent stem cells (iPSCs), and its overexpression leads to a high expression of the growth and differentiation factor 3 (GDF3), which affects animal growth traits. Therefore, the aim of this study...

Author(s)
Zhang Meng; Pan ChuanYing; Lin Qin; Hu SheNrong; Dang RuiHua; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2016, 59, 3, pp 351-361
Abstract

Paired-like homeodomain transcription factor 1 (PITX1) is a pivotal gene in the hypothalamic-pituitary-adrenal axis, which is a well-known pathway affecting lactation performance. The aim of this study was to analyze the DNA methylation profile of the PITX1 gene and its relevance to milk...

Author(s)
Zhao HaiYu; Zhang SiHuan; Wu XianFeng; Pan ChuanYing; Li XiangChen; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2019, 62, 1, pp 59-68
Abstract

The PROP1 protein, encoded by the prophet of Pit-1 (PROP1) gene, exhibits both DNA-binding and transcriptional activation abilities. Its expression leads to the ontogenesis of growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (TSH), and pituitary hormone. The missense mutation H173R ...

Author(s)
Pan ChuanYing; Wu ChongYang; Jia WenChao; Xu Yao; Lei ChuZhao; Hu ShenRong; Lan XianYong; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2013, 531, 2, pp 398-402
AbstractFull Text

In the process of anterior pituitary gland development and maturation, numerous transcription factors were involved in the pituitary organogenesis. To date, the lack of knowledge on POU1F1-PROP1-PITX1-SIX3 pathway genes affecting growth traits was reported in Chinese goat breeds. The objective of...

Author(s)
Ma Lin; Qin QiaoMei; Yang Qing; Zhang Meng; Zhao HaiYu; Pan ChuanYing; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
National Research Institute of Animal Production, Kraków, Poland
Citation
Annals of Animal Science, 2017, 17, 2, pp 399-411
Abstract

The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the...

Author(s)
Zhang XiaoYan; Wu XianFeng; Jia WenChao; Pan ChuanYing; Li XiangCheng; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Asian-Australasian Association of Animal Production Societies, Seoul, Korea Republic
Citation
Asian-Australasian Journal of Animal Sciences, 2015, 28, 10, pp 1394-1406
Abstract

Signal transducer and activator of transcription 5A (STAT5A), previously known as mammary gland factor (MGF), belongs to the prolactin/JAK2/STAT5 pathway, and plays an important role in growth and development, milking, and lipid accumulation in mammals. The aim of this study was to identify novel...

Author(s)
Wu XianFeng; Jia WenChao; Zhang JingJing; Li XiangCheng; Pan ChuanYing; Lei ChuZhao; Chen Hong; Dang RuiHua; Lan XianYong
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Small Ruminant Research, 2014, 121, 2/3, pp 232-243

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