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Abstract

Skeletal muscle development is regulated by a series of regulatory factors, and also including noncoding RNA, especially microRNAs (miRNAs). Recently, miR-148a has been found to be involved in murine C2C12 differentiation by targeting ROCK1. However, the function of miR-148a-3p for the...

Author(s)
Song ChengChuang; Yang JiaMeng; Jiang Rui; Yang ZhaoXin; Li Hui; Huang YongZhen; Lan XianYong; Lei ChuZhao; Ma Yun; Qi XingLei; Chen Hong
Publisher
Wiley, Hoboken, USA
Citation
Journal of Cellular Physiology, 2019, 234, 9, pp 15742-15750
Abstract

Nanog is an important pluripotent transcription regulator transforming somatic cells to induced pluripotent stem cells (iPSCs), and its overexpression leads to a high expression of the growth and differentiation factor 3 (GDF3), which affects animal growth traits. Therefore, the aim of this study...

Author(s)
Zhang Meng; Pan ChuanYing; Lin Qin; Hu SheNrong; Dang RuiHua; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2016, 59, 3, pp 351-361
Abstract

SMAD3, the messenger of the transforming growth factor beta (TGF-β) signaling pathway, plays essential roles in myogenesis and osteogenesis and may relate to the regulation of body weight. In this study, a 17 bp indel (NC_007308: g.101893_101909 insGAGGATGAGTGCTCCAG) in intron3 of the SMAD3 gene...

Author(s)
Shi Tao; Peng WenWen; Yan JianYu; Cai HanFang; Lan XianYong; Lei ChuZhao; Bai YueYu; Chen Hong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2016, 59, 1, pp 151-157
Abstract

Paired-like homeodomain transcription factor 1 (PITX1) is a pivotal gene in the hypothalamic-pituitary-adrenal axis, which is a well-known pathway affecting lactation performance. The aim of this study was to analyze the DNA methylation profile of the PITX1 gene and its relevance to milk...

Author(s)
Zhao HaiYu; Zhang SiHuan; Wu XianFeng; Pan ChuanYing; Li XiangChen; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2019, 62, 1, pp 59-68
Abstract

Cell death-inducing DFFA-like effector c (CIDEC, also known as Fsp27) has emerged as an important regulator of metabolism associated with lipodystrophy, diabetes, and hepatic steatosis. It is required for unilocular lipid droplet formation and optimal energy storage. The mechanism between this gene ...

Author(s)
Wang Jing; Hua LiuShuai; Pan Hong; Zhang LiangZhi; Li MingXun; Huang YongZhen; Li ZhuanJian; Lan XianYong; Lei ChuZhao; Li CongJun; Chen Hong
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2015, 5, 1, pp 12075
Abstract

Copy number variations (CNVs) have been recently recognized as another important genetic variability complementary to single nucleotide polymorphisms (SNPs). Compelling evidence has indicated that CNVs are responsible for phenotypic traits by changing the copy numbers of functional genes. Myosin...

Author(s)
Xu Yao; Shi Tao; Cai HanFang; Zhou Yang; Lan XianYong; Zhang ChunLei; Lei ChuZhao; Qi XingLei; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2014, 535, 2, pp 106-111
Abstract

Sonic Hedgehog (Shh) regulates many key developmental processes during vertebrate limb development, fat formation, and skeletal tissue regeneration. Current whole genome sequencing data have identified a copy number variation mapping to bovine Sonic Hedgehog gene (SHH-CNV). The object of this study ...

Author(s)
Liu Mei; Li Bo; Shi Tao; Huang YongZhen; Liu, G. E.; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Journal of Applied Genetics, 2019, 60, 2, pp 199-207
Abstract

Copy number variations (CNVs) recently have been recognized as an important source of genetic variability. Compelling evidence has indicated that CNVs are responsible for phenotypic traits by altering the copy numbers of functional genes. The molecule interacting with CasL-like protein 2 (MICAL-L2) ...

Author(s)
Xu Yao; Zhang LiangZhi; Shi Tao; Zhou Yang; Cai HanFang; Lan XianYong; Zhang ChunLei; Lei ChuZhao; Chen Hong
Publisher
Springer, New York, USA
Citation
Mammalian Genome, 2013, 24, 11/12, pp 508-516
Abstract

Zinc finger, BED-type containing 6 (ZBED6) is an important transcription factor in placental mammals, affecting development, cell proliferation and growth. Polymorphisms in its promoter and coding regions are likely to impact ZBED6 transcription and growth traits. In this study, rapid amplification ...

Author(s)
Huang YongZhen; Li MingXun; Wang Jing; Zhan ZhaoYang; Sun YuJia; Sun JiaJie; Li CongJun; Lan XianYong; Lei ChuZhao; Zhang ChunLei; Chen Hong
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2013, 8, 11, pp e79744
Abstract

The insulin-like growth factor 1 receptor (IGF1R) plays a vital role in immunomodulation and muscle and bone growth. The copy number variation (CNV) is believed to the reason for many complex phenotypic variations. In this paper, we statistically analyzed the copy number and the expression...

Author(s)
Ma YiLei; Wen YiFan; Cao XiuKai; Cheng Jie; Huang YongZhen; Ma Yun; Hu LinYong; Lei ChuZhao; Qi XingLei; Cao Hui; Chen Hong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2019, 62, 1, pp 171-179

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