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Abstract

We report genome characterization of three native Chinese cattle breeds discovering ∼34.3 M SNPs and ∼3.8 M InDels using whole genome resequencing. On average, 10.4 M SNPs were shared amongst the three cattle breeds, whereas, 3.0 M, 4.9 M and 5.8 M were specific to LQ, WN and WS breeds,...

Author(s)
Zhang FengWei; Qu KaiXing; Chen NingBo; Hanif, Q.; Jia YuTang; Huang YongZhen; Dang RuiHua; Zhang JiCai; Lan XianYong; Chen Hong; Huang BiZhi; Lei ChuZhao
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2019, 9, 9, pp 596
Abstract

The potassium inwardly rectifying channel, subfamily J, member 12 (KCNJ12) gene is a promising candidate for economic traits because of its crucial roles in myoblast development. Here, a missense mutation (Cys > Arg) was first detected to be located in exon 3 of KCNJ12 from three Chinese cattle...

Author(s)
Cheng Jie; Peng WenWen; Cao XiuKai; Huang YongZhen; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2019, 9, 5, pp 273
Abstract

Our previous work reported a relationship between FOXO1 mutations and growth of Qinchuan (QC) cattle. Here, we performed differential expression analysis of FOXO1 and its association analysis with growth traits in QC cattle. First, we measured the expression of the FOXO1 gene in nine tissues during ...

Author(s)
Sun YuJia; Liu KunPeng; Huang YongZhen; Lan XianYong; Chen Hong
Publisher
Science China Press, co-published with Springer, Berlin, Germany
Citation
Science China Life Sciences, 2018, 61, 7, pp 826-835
Abstract

Circular RNA (circRNA) is a new class of non-coding RNA that has recently attracted researchers' interest. Studies have demonstrated that circRNA can function as microRNA sponges or competing endogenous RNAs. Although circRNA has been explored in some species and tissues, the genetic basis of...

Author(s)
Gao Yuan; Wu MingLi; Fan YingZhi; Li ShiPeng; Lai ZhenYu; Huang YongZhen; Lan XianYong; Lei ChuZhao; Chen Hong; Dang RuiHua
Publisher
Royal Society, London, UK
Citation
Royal Society Open Science, 2018, 5, 7, pp 180413
Abstract

Paired box 7 (PAX7) gene regulates the conversion of muscle satellite cells into myogenic cells and participates in multi-step processes in myogenesis. Expression levels of PAX7 are decisive for its regulatory function. Previous reports revealed that PAX7 were responsible for the developmental...

Author(s)
Xu Yao; Shi Tao; Zhou Yang; Liu Mei; Klaus, S.; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2018, 8, 1, pp 1724
Abstract

Angiopoietin-like protein 6, which is encoded by ANGPTL6 gene (also known as angiopoietin growth factor, AGF), has been extensively characterized with regard to its proposed functions as angiogenesis and energy metabolism. The present results showed the occurrence of alternative splicing by intron...

Author(s)
Wu JiYao; Li AiMin; Cai HanFang; Zhang ChenGe; Lei ChuZhao; Lan XianYong; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2019, 709, pp 17-24
Abstract

Growth traits are complex quantitative traits controlled by numerous candidate genes, and they can be well-evaluated using body measurement traits. As the members of the nicotinamide adenine dinucleotide-dependent family of histone deacetylases, class I sirtuin genes (including SIRT1, SIRT2 and ...

Author(s)
Jin YunYun; Yang Qing; Gao JiaYang; Tang Qi; Duan Bo; Yu Ting; Qi XingLei; Liu JiMing; Wang RongMin; Dang RuiHua; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Springer, New York, USA
Citation
Biochemical Genetics, 2018, 56, 6, pp 663-676
Abstract

SMAD3, the messenger of the transforming growth factor beta (TGF-β) signaling pathway, plays essential roles in myogenesis and osteogenesis and may relate to the regulation of body weight. In this study, a 17 bp indel (NC_007308: g.101893_101909 insGAGGATGAGTGCTCCAG) in intron3 of the SMAD3 gene...

Author(s)
Shi Tao; Peng WenWen; Yan JianYu; Cai HanFang; Lan XianYong; Lei ChuZhao; Bai YueYu; Chen Hong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2016, 59, 1, pp 151-157
Abstract

Copy number variation (CNV) is a main and prevalent structural alterations underlying evolution of animal, which is considered to affect gene expression and complex traits. In this study, we analyzed genomic characteristics of CNV regions (CNVRs) in 254 Qinchuan cattle using GeneSeek HD 77k...

Author(s)
Huang JiePing; Li Ran; Zhang Xin; Huang YongZhen; Dang RuiHua; Lan XianYong; Chen Hong; Lei ChuZhao
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Livestock Science, 2017, 204, pp 88-91
Abstract

Testis development and spermatogenesis are strictly regulated by numbers of genes and non-coding genes. However, long non-coding RNAs (lncRNAs) as key regulators in multitudinous biological processes have not been systematically identified in bovine testes during sexual maturation. In this study,...

Author(s)
Gao Yuan; Li ShiPeng; Lai ZhenYu; Zhou ZiHui; Wu Fei; Huang YongZhen; Lan XianYong; Lei ChuZhao; Chen Hong; Dang RuiHua
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Genetics, 2019, 10, July, pp 646

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