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Abstract

Activation associated secreted proteins (ASP) are members of a nematode-specific protein family belonging to the SCP/Tpx-1/Ag5/PR-1/Sc7 family. Three different types of molecules have been identified in this family: two-domain ASPs and single-domain ASPs showing homology to either the C-terminal or ...

Author(s)
Visser, A.; Zeveren, A. M. van; Meyvis, Y.; Peelaers, I.; Broeck, W. van den; Gevaert, K.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
International Journal for Parasitology, 2008, 38, 3/4, pp 455-465
Abstract

Previous vaccination trials with calves have shown that intramuscular immunization with natively purified activation-associated secreted proteins (ASPs) of Ostertagia ostertagi induces protection against a homologous challenge infection with a 74% reduction in cumulative faecal egg counts and a...

Author(s)
Meyvis, Y.; Callewaert, N.; Gevaert, K.; Timmerman, E.; Durme, J. van; Schymkowitz, J.; Rousseau, F.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
Molecular and Biochemical Parasitology, 2008, 161, 1, pp 67-71
Abstract

Previous vaccination trials against Ostertagia ostertagi in cattle have demonstrated the protective capacity of a protein fraction termed ES-thiol, which is enriched for activation-associated secreted proteins (ASPs) and cysteine proteases. In this study, ES-thiol was subfractionated through...

Author(s)
Meyvis, Y.; Geldhof, P.; Gevaert, K.; Timmerman, E.; Vercruysse, J.; Claerebout, E.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2007, 149, 3/4, pp 239-245
Abstract

Previous vaccination trials against the economically important cattle parasite Ostertagia ostertagi have indicated the protective capacity of activation-associated secreted proteins (ASPs). The further development of these antigens into a commercial vaccine will require their recombinant...

Author(s)
Geldhof, P.; Meyvis, Y.; Vercruysse, J.; Claerebout, E.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Parasite Immunology, 2008, 30, 1, pp 57-60
Abstract

The translationally controlled tumour protein (TCTP) is a conserved protein which has been described for a wide range of eukaryotic organisms including protozoa, yeasts, plants, nematodes and mammals. Several parasitic organisms have been shown to actively secrete TCTP during host infection as part ...

Author(s)
Meyvis, Y.; Houthoofd, W.; Visser, A.; Borgonie, G.; Gevaert, K.; Vercruysse, J.; Claerebout, E.; Geldhof, P.
Publisher
Elsevier, Oxford, UK
Citation
International Journal for Parasitology, 2009, 39, 11, pp 1205-1213

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