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Abstract

Angiopoietin-like protein 6, which is encoded by ANGPTL6 gene (also known as angiopoietin growth factor, AGF), has been extensively characterized with regard to its proposed functions as angiogenesis and energy metabolism. The present results showed the occurrence of alternative splicing by intron...

Author(s)
Wu JiYao; Li AiMin; Cai HanFang; Zhang ChenGe; Lei ChuZhao; Lan XianYong; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2019, 709, pp 17-24
Abstract

Skeletal muscle development is regulated by a series of regulatory factors, and also including noncoding RNA, especially microRNAs (miRNAs). Recently, miR-148a has been found to be involved in murine C2C12 differentiation by targeting ROCK1. However, the function of miR-148a-3p for the...

Author(s)
Song ChengChuang; Yang JiaMeng; Jiang Rui; Yang ZhaoXin; Li Hui; Huang YongZhen; Lan XianYong; Lei ChuZhao; Ma Yun; Qi XingLei; Chen Hong
Publisher
Wiley, Hoboken, USA
Citation
Journal of Cellular Physiology, 2019, 234, 9, pp 15742-15750
Abstract

In this study, we detected the polymorphism of SNPs of intron 6 in CAPN4 gene in Datong Yak, Tianzhu White Yak, Gannan Yak and cattle by PCR-SSCP and DNA sequencing in order to understand the genetic characters of this gene in yak and cattle. The results showed that the 6 intron of CAPN4 gene in...

Author(s)
Zhang Li; Liu LiXia; Chen Hong; Yu LingXiao
Publisher
Guangxi University, Guangxi, China
Citation
Genomics and Applied Biology, 2017, 36, 12, pp 5099-5103
Abstract

Growth traits are complex quantitative traits controlled by numerous candidate genes, and they can be well-evaluated using body measurement traits. As the members of the nicotinamide adenine dinucleotide-dependent family of histone deacetylases, class I sirtuin genes (including SIRT1, SIRT2 and ...

Author(s)
Jin YunYun; Yang Qing; Gao JiaYang; Tang Qi; Duan Bo; Yu Ting; Qi XingLei; Liu JiMing; Wang RongMin; Dang RuiHua; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Springer, New York, USA
Citation
Biochemical Genetics, 2018, 56, 6, pp 663-676
Abstract

Copy number variation (CNV) of DNA sequences, functionally significant but yet fully ascertained, is believed to confer considerable increments in unexplained heritability of quantitative traits. Identification of phenotype-associated CNVs (paCNVs) therefore is a pressing need in CNV studies to...

Author(s)
Cao XiuKai; Huang YongZhen; Ma YiLei; Cheng Jie; Qu ZhenXian; Ma Yun; Bai YueYu; Tian Feng; Lin FengPeng; Ma YuLin; Chen Hong
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Functional & Integrative Genomics, 2018, 18, 5, pp 559-567
Abstract

Nanog is an important pluripotent transcription regulator transforming somatic cells to induced pluripotent stem cells (iPSCs), and its overexpression leads to a high expression of the growth and differentiation factor 3 (GDF3), which affects animal growth traits. Therefore, the aim of this study...

Author(s)
Zhang Meng; Pan ChuanYing; Lin Qin; Hu SheNrong; Dang RuiHua; Lei ChuZhao; Chen Hong; Lan XianYong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2016, 59, 3, pp 351-361
Abstract

SMAD3, the messenger of the transforming growth factor beta (TGF-β) signaling pathway, plays essential roles in myogenesis and osteogenesis and may relate to the regulation of body weight. In this study, a 17 bp indel (NC_007308: g.101893_101909 insGAGGATGAGTGCTCCAG) in intron3 of the SMAD3 gene...

Author(s)
Shi Tao; Peng WenWen; Yan JianYu; Cai HanFang; Lan XianYong; Lei ChuZhao; Bai YueYu; Chen Hong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2016, 59, 1, pp 151-157
Abstract

MiRNAs have emerged as key regulators of skeletal muscle development, but the knowledge of miRNAs in the molecular network of muscle development remains poorly understood. In this study, we designed to examine the biological function of bovine-miR-101-1. The bovine miR-101-1 was detected in the...

Author(s)
Wu JiYao; He DanDan; Yue BingLin; Zhang ChunLei; Fang XingTang; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2017, 636, pp 64-69
Abstract

Copy number variation (CNV) is a main and prevalent structural alterations underlying evolution of animal, which is considered to affect gene expression and complex traits. In this study, we analyzed genomic characteristics of CNV regions (CNVRs) in 254 Qinchuan cattle using GeneSeek HD 77k...

Author(s)
Huang JiePing; Li Ran; Zhang Xin; Huang YongZhen; Dang RuiHua; Lan XianYong; Chen Hong; Lei ChuZhao
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Livestock Science, 2017, 204, pp 88-91
Abstract

NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair regeneration of skeletal muscles. However, similar research on the bovine ...

Author(s)
Liu Mei; Zhang ChenGe; Lai XinSheng; Xue Jing; Lan XianYong; Lei ChuZhao; Jia YuTang; Chen Hong
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Journal of Applied Genetics, 2017, 58, 2, pp 241-247

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