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Abstract

Current evidences show that copy number variations (CNVs) are linked to complex phenotypic traits. Leptin receptor (LEPR) gene plays a critical role in energy homeostasis and fat development and re-sequencing of the cattle genome revealed the CNV region (herein referred to as "I3 DNA") within the ...

Author(s)
Shi Tao; Xu Yao; Yang MingJuan; Huang YongZhen; Lan XianYong; Lei ChuZhao; Qi XingLei; Yang XiaoMing; Chen Hong
Publisher
Wiley-Blackwell, Melbourne, Australia
Citation
Animal Science Journal, 2016, 87, 3, pp 336-343
Abstract

The identification of copy number variations (CNVs) allow us to explore genomic polymorphisms. In recent years, significant progress in understanding CNVs has been made in studies of human and animals, however, association and expression studies of CNVs are still in the early stage. It was...

Author(s)
Yang MingJuan; Lv JingQiao; Zhang LiangZhi; Li MingXun; Zhou Yang; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2017, 7, 1, pp 46599
Abstract

Background: Copy number variations (CNVs) are a main source of genomic structural variations underlying animal evolution and production traits. Here, with one pure-blooded Angus bull as reference, we describe a genome-wide analysis of CNVs based on comparative genomic hybridization arrays in 29...

Author(s)
Zhang LiangZhi; Jia ShanGang; Yang MingJuan; Xu Yao; Li, C. J.; Sun JiaJie; Huang YongZhen; Lan XianYong; Lei ChuZhao; Zhou Yang; Zhang ChunLei; Zhao Xin; Chen Hong
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2014, 15, 480, pp (17 June 2014)
Abstract

NPC1 gene is an important gene closely related to the Niemann-Pick type C (NPC). Mutations in the NPC1 gene tend to cause Niemann-Pick type C, a lysosomal storage disorder. Previous studies have shown that NPC1 protein plays an important role in subcellular lipid transport, homeostasis, platelet...

Author(s)
Dang YongLong; Li MingXun; Yang MingJuan; Cao XiuKai; Lan XianYong; Lei ChuZhao; Zhang ChunLei; Lin Qing; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2014, 540, 2, pp 153-160
Abstract

As an adaptor protein, apart from potentiating Janus kinase 2 (JAK2) activation and promoting the insulin signaling pathway, Src homology 2 B 2 (SH2B2) indirectly takes part in the regulation of glucose uptake through the c-Cb1/CAP/TC10 pathway, which can in turn affect growth. In this study, we...

Author(s)
Yang MingJuan; Fu JunHui; Lan XianYong; Sun YuJia; Lei ChuZhao; Zhang ChunLei; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2013, 528, 2, pp 314-319
Abstract

As an adaptor protein, SH2B1 is a key regulator of leptin sensitivity, energy balance, growth, and body weight. In this study, we identified three SNPs (snp796, snp823 and snp4368) of the SH2B1 gene in 1028 individuals from five Chinese cattle breeds by PCR-RFLP and sequencing, and investigated...

Author(s)
Yang MingJuan; Qu Lian; Liu JunXia; Lan XianYong; Zhang LiangZhi; Wang Jing; Lei ChuZhao; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Livestock Science, 2012, 143, 2/3, pp 283-288
Abstract

Beef production is an economically important sector of animal husbandry and much attention has been paid on the identification of molecular markers associated with gene expressions and growth traits. The aim of this study was to search for potential effects of a novel copy number variation (CNV)...

Author(s)
Liu Mei; Li Bo; Huang YongZhen; Yang MingJuan; Lan XianYong; Lei ChuZhao; Qu WeiDong; Bai YueYu; Chen Hong
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Livestock Science, 2016, 194, pp 44-50
Abstract

Adiponectin modulates lipid and glucose metabolism in adipose tissues and is also related to bone metabolism. Polymorphisms in the ADIPOQ gene likely have an impact on growth traits in cattle. In this study, we examined the relationship between ADIPOQ polymorphisms and body measurement parameters...

Author(s)
Zhang LiangZhi; Li MiJie; Lai XinSheng; Yang MingJuan; Xu Yao; Hua LiuShuai; Lan XianYong; Zhang ChunLei; Chen Hong
Publisher
NRC Research Press, Ottawa, Canada
Citation
Genome, 2013, 56, 7, pp 389-394
Abstract

Objective: The study was to study the polymorphism of the missense mutation in exon 1 of CCK gene and the association with the production traits in Nanyang cattle, in order to provide reference for the breeding of Chinese local cattle. Method: DNA sequencing and PCR-RFLP were applied to analyze the ...

Author(s)
Liu JunXia; Li Fei; Chen Hong; Yang MingJuan; Qu Lian; Lan XianYong
Publisher
Northwest A & F University (Natural Science Edition), Yangling, China
Citation
Journal of Northwest A & F University - Natural Science Edition, 2011, 39, 6, pp 25-30
Abstract

Cell death-inducing DFFA-like effector c (CIDEC) protein, also known as fat specific protein 27 (Fsp27), is localized to lipid droplets. CIDEC protein is required for unilocular lipid droplet formation and optimal energy storage in addition to controlling lipid metabolism in adipocytes and...

Author(s)
Wang Jing; Cao XiuKai; Pan Hong; Hua LiuShuai; Yang MingJuan; Lei ChuZhao; Lan XianYong; Chen Hong
Publisher
Springer, Amsterdam, Netherlands
Citation
Molecular Biology Reports, 2013, 40, 12, pp 6765-6774

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