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Abstract

Copy number variation (CNV) related to complex traits, such as disease and quantitative phenotype, is considered an important and wealthy source of genetic and phenotypic diversity. It suggests that the copy number variation of function gene maybe leads to the phenotypic changes. Kupple like factor ...

Author(s)
Xu JiaWei; Zheng Li; Li LiJuan; Yao YuFei; Hua He; Yang ShiZhen; Wen YiFan; Song ChengChuang; Cao XiuKai; Liu KunPeng; Zhang GuiMin; Yang JiaMeng; Hao Dan; Dang RuiHua; Lan XianYong; Lei ChuZhao; Qi XingLei; Chen Hong; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2019, 680, pp 99-104
Abstract

CNV1 and CNV2 of the GBP2 gene in 80 Qinchuan and 30 Jiaxian red cattle were detected by using quantitative real-time PCR (qPCR), respectively, to examine the variation of copy number and genetic effects of the GBP2 gene in Chinese cattle and the correlation of 2 CNV regions of GBP2 gene variation...

Author(s)
Zhang GuiMin; He Hua; Zheng Li; Song ChengChuang; Cao XiuKai; Wen YiFan; Lu QianQian; Lei ChuChao; Chen Hong; Huang YongZhen
Publisher
Guoji Shudian (Institute of Scientific and Technological Information of China, China Publications Centre), Beijing, China
Citation
Chinese Journal of Animal Science, 2018, 54, 1, pp 51-54, 64
Abstract

The potassium inwardly rectifying channel, subfamily J, member 12 (KCNJ12) gene is a promising candidate for economic traits because of its crucial roles in myoblast development. Here, a missense mutation (Cys > Arg) was first detected to be located in exon 3 of KCNJ12 from three Chinese cattle...

Author(s)
Cheng Jie; Peng WenWen; Cao XiuKai; Huang YongZhen; Lan XianYong; Lei ChuZhao; Chen Hong
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2019, 9, 5, pp 273
Abstract

Copy number variation (CNV) of DNA sequences, functionally significant but yet fully ascertained, is believed to confer considerable increments in unexplained heritability of quantitative traits. Identification of phenotype-associated CNVs (paCNVs) therefore is a pressing need in CNV studies to...

Author(s)
Cao XiuKai; Huang YongZhen; Ma YiLei; Cheng Jie; Qu ZhenXian; Ma Yun; Bai YueYu; Tian Feng; Lin FengPeng; Ma YuLin; Chen Hong
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Functional & Integrative Genomics, 2018, 18, 5, pp 559-567
Abstract

Myocyte enhancer factor 2C (MEF2C) gene was annotated for its potential phenotypic effects on bovine stature including body dimensions and body weight. The aim of this study was the analysis of MEF2C as a candidate for bovine stature. Four SNPs including two novel SNPs were identified and the...

Author(s)
Cao XiuKai; Zhan ZhaoYang; Huang YongZhen; Lan XianYong; Lei ChuZhao; Qi XingLei; Chen Hong
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Livestock Science, 2016, 185, pp 106-109
Abstract

NPC1 gene is an important gene closely related to the Niemann-Pick type C (NPC). Mutations in the NPC1 gene tend to cause Niemann-Pick type C, a lysosomal storage disorder. Previous studies have shown that NPC1 protein plays an important role in subcellular lipid transport, homeostasis, platelet...

Author(s)
Dang YongLong; Li MingXun; Yang MingJuan; Cao XiuKai; Lan XianYong; Lei ChuZhao; Zhang ChunLei; Lin Qing; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2014, 540, 2, pp 153-160
Abstract

Insulin-like growth factor 2 (IGF2) is a fetal growth and differentiation factor that plays an important role in muscle growth and in myoblast proliferation and differentiation. The aim of this study was to examine the association of the IGF2 polymorphism with growth traits in beef cattle breed....

Author(s)
Huang YongZhen; Wang Jing; Zhan ZhaoYang; Cao XiuKai; Sun YuJia; Lan XianYong; Lei ChuZhao; Zhang ChunLei; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2013, 528, 2, pp 139-145
Abstract

DNA methylation is a key epigenetic modification in mammals and has an essential and important role in muscle development. Insulin-like growth factor 2 (IGF2) is a fetal growth and differentiation factor that plays an important role in muscle growth and in myoblast proliferation and...

Author(s)
Huang YongZhen; Zhan ZhaoYang; Sun YuJia; Cao XiuKai; Li MingXun; Wang Jing; Lan XianYong; Lei ChuZhao; Zhang ChunLei; Chen Hong
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2014, 534, 2, pp 356-361
Abstract

The insulin-like growth factor 1 receptor (IGF1R) plays a vital role in immunomodulation and muscle and bone growth. The copy number variation (CNV) is believed to the reason for many complex phenotypic variations. In this paper, we statistically analyzed the copy number and the expression...

Author(s)
Ma YiLei; Wen YiFan; Cao XiuKai; Cheng Jie; Huang YongZhen; Ma Yun; Hu LinYong; Lei ChuZhao; Qi XingLei; Cao Hui; Chen Hong
Publisher
Copernicus Gesellschaft mbH, Gottingen, Germany
Citation
Archives Animal Breeding, 2019, 62, 1, pp 171-179
Abstract

Copy number variations (CNVs) recently have been recognized as another important genetic variability followed single nucleotide polymorphisms (SNPs). The guanylate binding protein 2 (GBP2) gene plays an important role in cell proliferation. This study was performed to determine the presence of GBP2 ...

Author(s)
Zhang GuiMin; Zheng Li; He Hua; Song ChengChuang; Zhang ZiJing; Cao XiuKai; Lei ChuZhao; Lan XianYong; Qi XingLei; Chen Hong; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2018, 647, pp 101-106

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